11 June 2020: Textbook Updates

We have posted updated reviews of the following topics:

Cervix > Carcinoma > Gastric type adenocarcinoma
by Gulisa Turashvili, M.D., Ph.D.
Topic summary: Common subtype of endocervical adenocarcinoma which includes minimal deviation adenocarcinoma. Not associated with HPV. Tumor cells usually contain tall apical mucin. New images, board review questions and more detailed histopathology.

Eye > Eyelid inflammatory disorders > Chalazion
by Pablo Zoroquiain, M.D.
Topic summary: Very common inflammatory eyelid lesion characterized by granulomatous inflammation with lipogranuloma, a central empty optic space surrounded by an epithelioid granuloma with multinucleated giant cells (foreign body type or touton). All specimens with tissue should be submitted to rule out malignant neoplasms and other masquerading conditions.

Pancreas > Exocrine tumors / carcinomas > Intraductal tubulopapillary neoplasm (ITPN)
by Gokce Askan, M.D., Olca Basturk, M.D.
Topic summary: Rare, intraductal, grossly solid and cystic, tubule forming, epithelial neoplasm with high grade dysplasia and no overt mucin production. Lacks genetic alterations commonly seen in IPMN. Favorable overall outcome even if associated with invasive carcinoma.

Skin nonmelanocytic tumor > Adnexal tumors – eccrine sweat glands > Digital papillary adenocarcinoma
by Haruto Nishida, M.D., Ph.D.
Topic summary: Malignant adnexal tumor with a marked predilection of acral site, usually fingers and toes. Tumor cells are basaloid / cuboidal to low columnar epithelial cells and myoepithelial cells with mild to moderate cytologic atypia.

Stains & molecular markers > PDL1 SP142
by Gary Tozbikian, M.D.
Topic summary: FDA approved companion diagnostic to atezolizumab for advanced / metastatic triple negative breast cancer (TNBC) and urothelial carcinoma. Scoring is evaluated in immune cell component using a proportion of tumor area scoring system; cutoffs are tumor site specific. Not interchangeable with other PDL1 assays (e.g. 22C3, SP263)