23 June 2020: Biweekly Image Quiz #33

Author: John DeWitt, M.D., Ph.D.

Which is true about this brain lesion presenting in a 50 year old man?

Select an answer:

A. R132H-IDH1 immunohistochemistry is negative, no further testing is necessary

B. If R132H-IDH1 immunohistochemistry is positive, ATRX staining of tumor cells is expected to be lost

C. If R132H-IDH1 immunohistochemistry is positive, ATRX staining of tumor cells is expected to be retained

D. If R132H-IDH1 immunohistochemistry is positive, p53 staining of tumor cells is expected to be weak and scattered

E. If R132H-IDH1 immunohistochemistry is positive, patient survival is similar to glioblastoma, IDH wildtype

To sign up for our biweekly image quiz newsletters and more, visit pathologyoutlines.com/subscribe.html.

To receive all PathologyOutlines.com updates directly to your email, follow our blog below: