23 June 2020: Biweekly Image Quiz #33

Author: John DeWitt, M.D., Ph.D.

Which is true about this brain lesion presenting in a 50 year old man?

Select an answer:

A. R132H-IDH1 immunohistochemistry is negative, no further testing is necessary

B. If R132H-IDH1 immunohistochemistry is positive, ATRX staining of tumor cells is expected to be lost

C. If R132H-IDH1 immunohistochemistry is positive, ATRX staining of tumor cells is expected to be retained

D. If R132H-IDH1 immunohistochemistry is positive, p53 staining of tumor cells is expected to be weak and scattered

E. If R132H-IDH1 immunohistochemistry is positive, patient survival is similar to glioblastoma, IDH wildtype

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