We have posted updated reviews of the following topics:Kidney tumor > General > Grossing
by Debra Zynger, M.D.
Topic summary: This topic describes how to gross specimens obtained from partial and radical nephrectomy procedures for suspected renal cortical tumors. Many high quality gross images are included.
Lung nontumor > Other interstitial pneumonitis / fibrosis > Respiratory bronchiolitis
by William Perry, M.D., M.P.H., Kristine Konopka, M.D.
Topic summary: Usually incidental but occasionally associated with interstitial lung disease. Seen in virtually all smokers. Characterized by lightly pigmented (smoker’s) macrophages in distal airways and peribronchiolar airspaces with variable mild inflammation and fibrosis.
Lymph nodes & spleen, nonlymphoid > Neoplasms (not lymphoma) > Histiocytic sarcoma
by Zenggang Pan, M.D., Ph.D.
Topic summary: Malignant proliferation of mature histiocytes, excluding dendritic cell neoplasms, Langerhans cell neoplasms and myeloid sarcomas with monocytic differentiation. Mostly extranodal. Diagnosis requires confirmation of cell origin by special studies. May mimic pleomorphic or spindle cell sarcoma.
Pleura & peritoneum > Pleura mesothelial tumors > Diffuse malignant mesothelioma
by Anja C. Roden, M.D.
Topic summary: Aggressive neoplasm of mesothelial differentiation- epithelioid, biphasic or sarcomatoid subtype. Most commonly associated with remote (up to 40 years prior) asbestos exposure. Loss of expression of BRCA1 associated protein (BAP1) or methylthioadenosine phosphorylase (MTAP) or homozygous deletion of cyclin dependent kinase inhibitor 2A (CDKN2A) (p16) by FISH helps to distinguish reactive mesothelial proliferation from malignant pleural mesothelioma
Stomach > Carcinoma > Gastric carcinoma with lymphoid stroma (lymphoepithelioma-like carcinoma, medullary carcinoma)
by Carolina Martinez-Ciarpaglini, M.D., Ph.D.
Topic summary: Infrequent gastric carcinoma composed of small nests of cancer cells broadly distributed in a background of dense and prominent lymphoid stroma, histologicically similar to nasopharyngeal carcinoma. Strongly associated with EBV infection and microsatellite instability (mutually exclusive). PDL1 is usually overexpressed, making these tumors prone to immune checkpoint blockade therapy.