26 January 2021: Image Quiz #48

Authors: Cade Arries, M.D., Elizabeth Courville, M.D.

A 45 year old man with a history of renal transplant presented with lymphadenopathy. A lymph node biopsy was performed. A representative image is shown. The large atypical cells are positive for CD30 and CD15 with dim PAX5 nuclear positivity and dim and variable CD20 expression. CD3 and CD45 are negative. Which of the following is the most appropriate diagnosis?

Select an answer:

A. Classic Hodgkin lymphoma posttransplant lymphoproliferative disorder

B. Monomorphic posttransplant lymphoproliferative disorder (diffuse large B cell lymphoma)

C. Nondestructive posttransplant lymphoproliferative disorder (florid follicular hyperplasia)

D. Polymorphic posttransplant lymphoproliferative disorder

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