15 February 2022: Image Quiz #76

Authors: Josephine K. Dermawan, M.D., Ph.D.Karen Fritchie, M.D.

A 54 year old woman presents with a 9.6 cm, well circumscribed, firm mass in the deep soft tissue of the thigh. Histologic sections show ovoid to spindled cells arranged haphazardly around prominent, thin walled, hyalinized, dilated, staghorn type vasculature (see image below). Which of the following is the most sensitive and specific immunohistochemical marker for the diagnosis of this tumor?

Select an answer:

A. Actin

B. BCL2

C. CD34

D. Cytokeratin CAM 5.2

E. STAT6

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