20 January 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Acute mastitis / abscess

Core needle biopsy from a 28 year old lactating woman. A dense inflammatory infiltrate is shown on the left, obscuring underlying breast parenchyma.

Contributed by Kristen E. Muller, D.O.

Prostate specific antigen (PSA)

PSA is focally positive, which is common in more poorly differentiated prostatic adenocarcinoma. Lung adenocarcinoma will not be positive for PSA, so this confirms metastatic prostatic adenocarcinoma. Of note, this patient had a clinical history of a prostatic adenocarcinoma.

Contributed by Heather I-Hsuan Chen-Yost, M.D.

Fibromatosis / fasciitis-like

Papillary thyroid carcinoma with fibromatosis / fasciitis-like stroma: myofibroblastic proliferation within collagenous stromal tissue.

Contributed by Ayana Suzuki, C.T.

Gunshot wounds

Soot deposition, searing of the skin and contusion surrounding the central defect.

Contributed by Lorenzo Gitto, M.D. and Robert Stoppacher, M.D.

How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 61 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

19 January 2021: PathologyOutlines.com 2021 Monthly Planners

We currently have 2021 monthly planners available on a first come first served basis. If you are interested in one, please send a request to kelli@pathologyoutlines.com with how many you are interested in along with your mailing address. 

15 January 2021: Weekly Roundup #32


This is what’s new on PathologyOutlines.com:

1. Dr. Pernick’s Curing Cancer Blog

Dr. Pernick has written his fourth essay about curing cancer based on complexity theory. Click here for a PDF download or read the essay here. You can also follow his blog for regular updates directly to your inbox. In part 3, he summarized recommendations on curative treatment for advanced adult cancers with a poor prognosis, such as lung and pancreatic cancer. In this essay, he discusses these principles of curative treatment in greater depth: network medicine, blocking multiple pathways, combinations of combinations of treatment, monitoring key networks, clinical trials and strong public health programs. He is happy to respond to comments or questions at Nat@PathologyOutlines.com.

See also Curing cancer, Part 1 – Reductionism vs. Complexity, Curing Cancer, Part 2 – Adult vs. Childhood Cancer and Curing Cancer – Part 3 – Curative cancer treatment based on complexity theory.

2. What’s New This Week Video

We have a new short video, This Week At PathologyOutlines.com, posted on our homepage and on our YouTube channel. We also have a text summary in the description box of the YouTube video if you are in a hurry.

3. New COVID-19 Article

Our COVID-19 library (click on “Libraries” in our site navigation, then select COVID-19 Library) has a new article, FDA Issues Alert Regarding SARS-CoV-2 Viral Mutation, posted 8 January 2021.

4. Case #499

Case #499 was posted on January 14. You can also sign up for our monthly case newsletters and more here.

5. Author Payment

As of September 2020, we stopped paying authors with 3+ topics, although we will honor payment to authors who wrote 3+ topics before the end of 2020. Please give us time to contact you about payment or feel free to contact us by 31 January 2021 at Authors@PathologyOutlines.com if you believe you are owed money for author topics.

6. Website Traffic in 2020

Despite the COVID-19 pandemic, our website traffic was still up 3.5% in 2020 compared to 2019. Average traffic in 2020 was 40,628 visits / day, with over 32 million pageviews sitewide. As always thank you for your support and please contact us at CommentsPathOut@gmail.com with any suggestions on how to improve the website.

14 January 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Adenomyoepithelioma

Higher power image of the breast lumpectomy specimen demonstrates the dual cell population of myoepithelial cells surrounding epithelial glands with luminal secretions. Diagnosis: adenomyoepithelioma.

Contributed by Hannah Y. Wen, M.D., Ph.D.

Liver hemangioma

Well circumscribed and nonencapsulated large mass with a red-brown color, focal honeycombed appearance, sponge-like consistency and foci of fibrosis.

Contributed by Lizhi Zhang, M.D.

Multicystic mesothelioma

Multicystic mesothelioma (top) involving the omentum (bottom). The lesion comprises multiple variably sized, predominantly collapsed cysts. It involves the omental surface without infiltration of underlying fat (H&E, whole slide).

Contributed by David B. Chapel, M.D.

Erythema elevatum diutinum

In the superficial dermis, there are dilated thin walled vessels and prominent fibrosis overlying a polymorphous inflammatory infiltrate in this established lesion (H&E, 40x).

Contributed by Kiran Motaparthi, M.D.

Ossifying fibromyxoid tumor

Ossifying fibromyxoid tumor. Nodular growth of uniform, round or ovoid cells with bland nuclei.

Contributed by Borislav A. Alexiev, M.D.

How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 61 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.


12 January 2021: Image Quiz #47

Author: Jian-Hua Qiao, M.D.

An 80 year old Caucasian woman had a thyroid mass and a 1 cm pulmonary lesion. CT guided transthoracic needle biopsy was performed to rule out metastatic tumor. Microscopic examination of core needle biopsy tissue reveals the following lesion. What is your diagnosis?

Select an answer:

A. Metastatic thyroid papillary carcinoma

B. Minute pulmonary meningothelial-like nodule

C. Pulmonary carcinoid tumor

D. Pulmonary meningioma

E. Pulmonary paraganglioma

To sign up for our biweekly image quiz newsletters and more, visit pathologyoutlines.com/subscribe.html.

8 January 2021: Weekly Roundup #31


Happy New Year! This is what’s new on PathologyOutlines.com:

1. Dr. Pernick’s Curing Cancer Blog

Dr. Pernick’s next short essay in his “Curing Cancer” blog series can be read here. It outlines his recommendations for curative treatment for advanced adult cancers with a poor prognosis, such as lung and pancreatic cancer. The main point is that advanced cancer is not just due to driver mutations but also to systemic network changes that will not revert to normal if the tumor is excised or destroyed. Email any comments or questions to Nat@PathologyOutlines.com.

See also Curing cancer, Part 1 – Reductionism vs. Complexity and Curing Cancer, Part 2 – Adult vs. Childhood Cancer.

2. Jobs Graph

We have a new Jobs graph that tracks the total number of jobs from January 2017 to date. Use the slide bar to focus on a particular time period.

3. Jobs Page Features

Below the blue box on our Jobs page you can find regularly updated lists of Pathology chairs and Residency directors. Use the Comment feature in the Header to tell us of any needed updates.

4. Website Navigation

To navigate more quickly, use the Breadcrumbs at the top and bottom of each topic page. You can also go back to the main chapter or our Home page.

5. E-blast Security

To improve security, we have added a “Double opt-in” feature for our E-blasts. This means that after you sign up, you will receive an email with a link to confirm that you really did make the changes. We have several hundred requests “in limbo”, so if you are not getting the E-blasts you signed up for, please subscribe again and confirm with the follow up email.

30 December 2020: Images of the Week

Here is a selection of new images from our free, online textbook:

MDM2

Corresponding MDM2 IHC in an atypical lipomatous tumor / well differentiated liposarcoma highlighting scattered nuclei within fibrous septa in a strong, diffuse pattern.

Contributed by Jennifer Yoest, M.D. (source: University of Michigan Virtual Slide Box)

Papillary thyroid carcinoma > Diffuse sclerosing

DSV PTC shows prominent and extensive intratumoral interstitial sclerotic stroma. Malignant cells grow in an irregular infiltrative pattern and show typical nuclear features of PTC.

Contributed by Livia Florianova, M.D., M.Sc. and Marc Pusztaszeri, M.D.

Chondromyxoid fibroma

The cellular population within the nodules shows spectrum of differentiation, comprising of stellate to spindle mesenchymal cells in a myxoid background at one end, as seen in this example, to well developed hyaline cartilaginous differentiation on the other end.

Contributed by Nasir Ud Din, M.B.B.S.

Placenta accreta, increta and percreta

A chorionic villous implants directly onto myometrial fibers with no intervening decidua.

Contributed by Fabiola Medeiros, M.D.

Fibroepithelial (stromal) polyp

Fibroepithelial polyp excision showing polypoid lesion with stromal component extending up to epithelium.

Contributed by Albert Alhatem, M.D. and Debra S. Heller, M.D.

How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 61 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.


29 December 2020: Image Quiz #46

Authors: Aysha Mubeen, M.D.Arun Gopinath, M.D.

The grossing protocol for examination of the fallopian tube to identify the diagnosis in the photomicrograph should:

Select an answer:

A. Ensure complete evaluation of the fallopian tube in all cases

B. Increase detection of precursor lesions in at risk women

C. Require multistep levels in at risk women

D. Require tangential sectioning of the infundibulum and fimbrial segment to allow maximal exposure

To sign up for our biweekly image quiz newsletters and more, visit pathologyoutlines.com/subscribe.html.

24 December 2020: Weekly Roundup #30


This is what’s new on PathologyOutlines.com this week:

1. Welcome Jose Mantilla, M.D. to our Editorial Board

Congratulations to new Editorial Board member Jose Mantilla, M.D. Dr. Mantilla is an Acting Assistant Professor of Laboratory Medicine and Pathology and Associate Program Director of the Surgical Pathology fellowship at the University of Washington in Seattle. He obtained his M.D. at the Pontificia Universidad Javeriana (Bogotá, Colombia), followed by a residency in Anatomic and Clinical Pathology at Montefiore Medical Center in New York and fellowships in Surgical Pathology and Bone and Soft Tissue Pathology at the University of Washington. He will oversee Bone and Soft tissue with Dr. Borislav A. Alexiev.

2. Dr. Pernick’s Curing Cancer Blog

Dr. Pernick’s next short essay in his “Curing Cancer” blog series can be read here. To cure adult cancers, he suggests emulating our success with curing cancer in children and young adults by using even larger numbers of combinations of treatments and enrolling more patients in clinical trials. Email comments or questions to NatPernick@gmail.com.

3. Secure Website

Our website is now secure. While this is not terribly significant since we don’t collect information from our website’s visitors, the “not secure” flags may be off-putting for some people. It took us 2 years to make the switch because we needed to inspect 40K+ images and links and correct them if they were associated with unsecure websites. We are working on a few pages that still may be unsecured so feel free to notify Dr. Pernick at Nat@PathologyOutlines.com if you have any follow-up questions or comments.

4. What’s New This Week

We have a new short video, This Week At PathologyOutlines.com, posted on our homepage and on our YouTube channel. We also have a text summary in the description box of the YouTube video if you are in a hurry.

18 December 2020: New Transfusion Medicine Topics

Interested in Transfusion Medicine? We have many newly written topics over the past 6 months and more to come:

Make sure to check out the entire transfusion medicine chapter on our website:

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