Author: Raul S. Gonzalez, M.D.
Which of the following typically causes bland cholestasis as seen on a liver biopsy?
Select an answer:
A. Amoxicillin / clavulanate injury
B. Anabolic steroid injury
C. Chronic large duct obstruction
D. Primary biliary cholangitis
E. Primary sclerosing cholangitis
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Author: Gary Tozbikian, M.D.
A 25 year old woman presents with a 3 cm breast mass. An ultrasound guided biopsy shows a fibroepithelial lesion. Which histologic feature is consistent with a diagnosis of fibroadenoma?
Select an answer:
A. Circumscribed borders
B. Marked stromal cytologic atypia
C. Stromal condensation around glandular structures
D. Stromal mitotic activity (7 – 8/10 high power fields)
E. Stromal overgrowth
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Authors: Daffolyn Rachael Fels Elliott, M.D., Ph.D., Ryan M. Gill, M.D., Ph.D.
Which variant of hepatocellular carcinoma is shown in the image?
Select an answer:
A. Fibrolamellar
B. Lymphoepithelioma-like
C. Sarcomatoid
D. Scirrhous
E. Undifferentiated
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Author: Y. Albert Yeh, M.D., Ph.D.
What is the most common pathogen of bladder schistosomiasis?
Select an answer:
A. Schistosoma haematobium
B. Schistosoma haematobium – Schistosoma mansoni hybrid
C. Schistosoma intercalatum
D. Schistosoma japonicum
E. Schistosoma mansoni
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Author: Raul S. Gonzalez, M.D.
Where are VIPomas most likely to arise?
Select an answer:
A. Body of the pancreas
B. Duodenum
C. Head of the pancreas
D. Ileum
E. Tail of the pancreas
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Authors: Nathan Lee, D.M.D., Tony Ng, M.D., Ph.D.
A 26 year old man with an upper lip laceration from a motor vehicle accident presented with a localized swelling, biopsy shown below. What immunohistochemical finding would one expect?
Select an answer:
A. CD68 positive
B. Cytokeratin positive
C. PAX8 positive
D. S100 positive
E. SMA positive
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Authors:  Min Shi, M.D., Ph.D., Dragan Jevremovic, M.D., Ph.D.
Which genetic abnormality is used to define T prolymphocytic leukemia?
Select an answer:
A. 17p (TP53) deletion
B. CCND1 rearrangement
C. MYC rearrangement
D. TCL1 rearrangement
E. TP53 mutations
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Authors: Sarah Findeis, M.D., He Huang, M.D., Ph.D.
A single discrete lesion is identified within the prostate. What immunohistochemical profile would you expect to have with the following prostatic tumor?
Select an answer:
A. CDX2+, AMACR+, PSAP+
B. NKX3.1+, CK20-, PSA+
C. PSA+, CK7+, AMACR+
D. CK5+, CK20+, NKX3.1+
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Author: Pablo Zoroquiain, M.D.
What finding in this sample is characteristic of pterygium?
Select an answer:
A. Bowman’s layer fragmentation
B. Elastosis of the lamina propria with corneal invasion
C. Epithelial atrophy with goblet cell loss
D. Neovascularization of the stroma
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Authors: Vikas Mehta, M.D., Maria M. Picken, M.D., Ph.D.
What is the immunohistochemical staining pattern of adenovirus in adenovirus nephritis?
Select an answer:
A. Cytoplasmic
B. Dot-like
C. Nuclear
D. Nuclear and cytoplasmic
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