11 January 2022: Image Quiz #73

Author: Raul S. Gonzalez, M.D.

Which of the following typically causes bland cholestasis as seen on a liver biopsy?

Select an answer:

A. Amoxicillin / clavulanate injury

B. Anabolic steroid injury

C. Chronic large duct obstruction

D. Primary biliary cholangitis

E. Primary sclerosing cholangitis

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28 December 2021: Image Quiz #72

Author: Gary Tozbikian, M.D.

A 25 year old woman presents with a 3 cm breast mass. An ultrasound guided biopsy shows a fibroepithelial lesion. Which histologic feature is consistent with a diagnosis of fibroadenoma?

Select an answer:

A. Circumscribed borders

B. Marked stromal cytologic atypia

C. Stromal condensation around glandular structures

D. Stromal mitotic activity (7 – 8/10 high power fields)

E. Stromal overgrowth

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14 December 2021: Image Quiz #71

Authors: Daffolyn Rachael Fels Elliott, M.D., Ph.D.Ryan M. Gill, M.D., Ph.D.

Which variant of hepatocellular carcinoma is shown in the image?

Select an answer:

A. Fibrolamellar

B. Lymphoepithelioma-like

C. Sarcomatoid

D. Scirrhous

E. Undifferentiated

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30 November 2021: Image Quiz #70

Author: Y. Albert Yeh, M.D., Ph.D.

What is the most common pathogen of bladder schistosomiasis?

Select an answer:

A. Schistosoma haematobium

B. Schistosoma haematobium – Schistosoma mansoni hybrid

C. Schistosoma intercalatum

D. Schistosoma japonicum

E. Schistosoma mansoni

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16 November 2021: Image Quiz #69

Author: Raul S. Gonzalez, M.D.

Where are VIPomas most likely to arise?

Select an answer:

A. Body of the pancreas

B. Duodenum

C. Head of the pancreas

D. Ileum

E. Tail of the pancreas

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2 November 2021: Image Quiz #68

Authors: Nathan Lee, D.M.D., Tony Ng, M.D., Ph.D.

A 26 year old man with an upper lip laceration from a motor vehicle accident presented with a localized swelling, biopsy shown below. What immunohistochemical finding would one expect?

Select an answer:

A. CD68 positive

B. Cytokeratin positive

C. PAX8 positive

D. S100 positive

E. SMA positive

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19 October 2021: Image Quiz #67

Authors:  Min Shi, M.D., Ph.D.Dragan Jevremovic, M.D., Ph.D.

Which genetic abnormality is used to define T prolymphocytic leukemia?

Select an answer:

A. 17p (TP53) deletion

B. CCND1 rearrangement

C. MYC rearrangement

D. TCL1 rearrangement

E. TP53 mutations

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5 October 2021: Image Quiz #66

Authors: Sarah Findeis, M.D.He Huang, M.D., Ph.D.

A single discrete lesion is identified within the prostate. What immunohistochemical profile would you expect to have with the following prostatic tumor?

Select an answer:

A. CDX2+, AMACR+, PSAP+

B. NKX3.1+, CK20-, PSA+

C. PSA+, CK7+, AMACR+

D. CK5+, CK20+, NKX3.1+

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21 September 2021: Image Quiz #65

Author: Pablo Zoroquiain, M.D.

What finding in this sample is characteristic of pterygium?

Select an answer:

A. Bowman’s layer fragmentation

B. Elastosis of the lamina propria with corneal invasion

C. Epithelial atrophy with goblet cell loss

D. Neovascularization of the stroma

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7 September 2021: Image Quiz #64

Authors: Vikas Mehta, M.D., Maria M. Picken, M.D., Ph.D.

What is the immunohistochemical staining pattern of adenovirus in adenovirus nephritis?

Select an answer:

A. Cytoplasmic

B. Dot-like

C. Nuclear

D. Nuclear and cytoplasmic

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