Authors: Akira Yoshikawa, M.D., Andrey Bychkov, M.D., Ph.D.
Which phase of diffuse alveolar damage (DAD) is most clearly demonstrated in this histological image?
Select an answer:
A. Active
B. Exudative (acute)
C. Fibrotic (chronic)
D. Postinflammatory
E. Proliferative / organizing (subacute)
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Author: Nick Baniak, M.D.
A 67 year old man presents with a solitary liver lesion. Glypican 3 staining was performed as part of a panel (see image below). What is the most likely diagnosis?
Select an answer:
A. Cirrhotic nodule
B. Focal nodular hyperplasia
C. Hepatic adenoma
D. Hepatocellular carcinoma
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Authors: Susan Prendeville, M.D., Bonnie Choy, M.D.
A 65 year old man underwent radical cystectomy for a bladder mass and the entire tumor looked like the histologic image shown below. Which of the following is true regarding this type of tumor arising in the urinary bladder?
Select an answer:
A. Gross examination usually shows a small tumor
B. Hematuria is not a clinical feature
C. It is associated with Schistosoma haematobium infection
D. It is the most common type of bladder carcinoma
E. Smoking is not a risk factor
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Authors: Matthew Franklin, M.D., Stephen Somach, M.D.
The photomicrograph shown below depicts an excision specimen from a carpenter presenting with a painful nodule of the right palm. What is the diagnosis?
Select an answer:
A. Epidermoid cyst
B. Foreign body granuloma
C. Osteoma cutis
D. Pilomatricoma
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Authors: Juwairiya Arshi, M.B.B.S., Aaron R. Huber, D.O.
Which histological feature is most common in celiac disease?
Select an answer:
A. Crypt hyperplasia
B. Granulomas
C. Intraepithelial lymphocytosis
D. Mucosal eosinophilia
E. Villous atrophy
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Authors: Samuel Bidot, M.D., Saja Asakrah, M.D., Ph.D.
This specimen is a touch imprint obtained from an axillary lymph node of a 35 year old white man with HIV. Which of the following viruses is associated with this disease and with what frequency?
Select an answer:
A. Epstein-Barr virus in 30% of cases
B. Epstein-Barr virus in > 95% of cases
C. Human herpesvirus 8 in 50% of cases
D. Human herpesvirus 8 in > 95% of cases
E. Human T cell leukemia virus type 1 in > 95% of cases
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Author: Shreeram Akilesh, M.D., Ph.D.
A patient with COVID-19 presents with nephrotic range proteinuria and the finding on the kidney biopsy is shown below. Mutations in which gene are linked with a higher risk of developing this pathologic lesion in the kidney?
Select an answer:
A. APOL1
B. CD2AP
C. FANCD2
D. LRP2
E. NPHS1
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Authors: Rebecca Yoda, M.D., P.J. Cimino, M.D., Ph.D.
This IDH mutant astrocytoma is from a 40 year old woman. There is no microvascular proliferation or necrosis identified. According to the 5th edition of the WHO classification of CNS tumors (2021), a CNS WHO grade 4 should be applied if which of the following genetic alterations is present?
Select an answer:
A. ATRX loss
B. CDKN2A homozygous deletion
C. Chromosome 1p / 19q codeletion
D. EGFR amplification
E. TERT promoter mutation
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Authors: Laura Warmke, M.D., Jeanne Meis, M.D.
Which of the following special stains is most helpful in diagnosing alveolar soft part sarcoma (ASPS)?
Select an answer:
A. Colloidal iron
B. GMS
C. PAS with diastase
D. PAS without diastase
E. Warthin-Starry
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Author: Abberly Lott Limbach, M.D.
A 45 year old patient presents with a painless 0.5 cm white nodule on the left lateral tongue. A biopsy is performed and a representative image from the histology is shown below. What is the diagnosis?
Select an answer:
A. Fordyce granule
B. Lymphoepithelial cyst
C. Lymphoid aggregate
D. Mucocele
E. Sialolith
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