Authors: Ameya Patil, M.D., M.S., Lizhi Zhang, M.D.
Which cell type (marked by an arrow) is considered abnormal if present in the left side of the colon?
Select an answer:
A. Enteroendocrine cells
B. Epithelial cells
C. Goblet cells
D. Paneth cells
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Author: Jordan M. Hall, M.D.
Which of the following is detected in the tumor cells of fibrin associated diffuse large B cell lymphoma?
Select an answer:
A. EBV
B. HHV8
C. HIV
D. HSV
E. KSHV
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Authors: Simon F. Roy, M.D., Jennifer M. McNiff, M.D.
What is the histopathological epidermal reaction pattern seen in the image below?
Select an answer:
A. Acantholysis
B. Dyskeratotic acantholysis
C. Epidermal necrosis
D. Epidermolytic hyperkeratosis
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Author: Molly Housley Smith, D.M.D.
Oral examination of a patient reveals an asymmetric 4 mm red nodule at the dorsal tongue base. The patient is asymptomatic and was unaware of the finding. Biopsy of the lesion is shown. Which of the following is true regarding the diagnosis?
Select an answer:
A. Diagnosis of this entity relies heavily on immunohistochemical findings
B. Diagnosis represents reactive hyperplasia of a normal structure
C. Significant clinical follow up is recommended, since malignant transformation occurs in the majority of patients with this finding
D. This entity is more commonly found in older adults
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Authors: Timothy Isaac Miller, M.D., M.A., Maria Tretiakova, M.D., Ph.D.
Which of the following is the most likely immunohistochemical profile of the renal neoplasm shown?
Select an answer:
A. CK7+, KIT+, vimentin-, CAIX-
B. CK7+, KIT+, vimentin-, CAIX+
C. CK7+, KIT+, vimentin+, CAIX-
D. CK7-, KIT+, vimentin-, CAIX-
E. CK7-, KIT-, vimentin+, CAIX+
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Author: Jijgee Munkhdelger, M.D., Ph.D., Andrey Bychkov, M.D., Ph.D.
What is a widely used IHC marker for Langerhans cell histiocytosis?
Select an answer:
A. CD1a
B. CD20
C. Cytokeratin
D. Thyroglobulin
E. TTF1
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Author: Y. Albert Yeh, M.D., Ph.D.
Which of the following biomarker expressions shown in the photomicrograph is lost in neuroendocrine carcinoma?
Select an answer:
A. CD56
B. Chromogranin
C. INSM1
D. YAP1
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Authors: Carissa LaBoy, M.D., Kalliopi P. Siziopikou, M.D., Ph.D.
What is the most likely hormone receptor profile of the following breast lesion?
Select an answer:
A. ER+, PR+, HER2-
B. ER-, PR-, HER2-
C. ER+, PR+, HER2+
D. ER-, PR+, HER2+
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Authors: Josephine K. Dermawan, M.D., Ph.D., Karen Fritchie, M.D.
A 54 year old woman presents with a 9.6 cm, well circumscribed, firm mass in the deep soft tissue of the thigh. Histologic sections show ovoid to spindled cells arranged haphazardly around prominent, thin walled, hyalinized, dilated, staghorn type vasculature (see image below). Which of the following is the most sensitive and specific immunohistochemical marker for the diagnosis of this tumor?
Select an answer:
A. Actin
B. BCL2
C. CD34
D. Cytokeratin CAM 5.2
E. STAT6
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Author: Varsha Manucha, M.D.
A 50 year old man with a long term history of urethral stricture and chronic cystitis presents with mucosuria. Cystoscopy reveals a papillary growth, which is biopsied and diagnosed as villous adenoma of the urinary bladder. What is the best treatment option for the patient?
Select an answer:
A. Bacillus Calmette-Guérin (BCG) therapy
B. Chemotherapy
C. Close follow up
D. Complete excision
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