Authors: Ruhani Sardana, M.B.B.S., Anil Parwani, M.D., Ph.D., M.B.A.
Which technique is shown in the image below?
Select an answer:
A. Electron microscopy
B. Enzyme linked immunosorbent assay
C. Fluorescent in situ hybridization
D. Immunofluorescence
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Authors: Zena Jameel, M.D., Marilin Rosa, M.D.
Which of the following is a relevant feature of invasive papillary carcinoma of the breast?
Select an answer:
A. Commonly encountered breast tumor
B. Graded according to nuclear size
C. May mimic metastases from other organs
D. Myoepithelial cells at the periphery
E. Positive for Napsin A and PAX8
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Authors: Christopher Dall, M.D., Debra L. Zynger, M.D.
Teratoma with somatic type malignancy most commonly contains which histologic type?
Select an answer:
A. Adenocarcinoma
B. Primitive neuroectodermal tumor
C. Rhabdomyosarcoma
D. Sarcoma, not otherwise specified
E. Squamous cell carcinoma
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Authors: Simona De Michele, M.D., Helen E. Remotti, M.D.
When evaluating the pulmonary neoplasm shown in the image, which immunohistochemical stain is more specific than CDX2 for ruling in a colorectal metastasis?
Select an answer:
A. CK7
B. CK20
C. Napsin A
D. SATB2
E. TTF1
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Authors: Jutta Huvila, M.D., Ph.D., C. Blake Gilks, M.D.
Which of the following is true about benign Brenner tumors of the ovary?
Select an answer:
A. Composed of both epithelium and fibromatous stroma
B. Papillary architecture
C. Typically > 10 cm
D. Usually present with abdominal pain
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Authors: Ameya Patil, M.D., M.S., Lizhi Zhang, M.D.
Which cell type (marked by an arrow) is considered abnormal if present in the left side of the colon?
Select an answer:
A. Enteroendocrine cells
B. Epithelial cells
C. Goblet cells
D. Paneth cells
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Author: Jordan M. Hall, M.D.
Which of the following is detected in the tumor cells of fibrin associated diffuse large B cell lymphoma?
Select an answer:
A. EBV
B. HHV8
C. HIV
D. HSV
E. KSHV
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Authors: Simon F. Roy, M.D., Jennifer M. McNiff, M.D.
What is the histopathological epidermal reaction pattern seen in the image below?
Select an answer:
A. Acantholysis
B. Dyskeratotic acantholysis
C. Epidermal necrosis
D. Epidermolytic hyperkeratosis
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Author: Molly Housley Smith, D.M.D.
Oral examination of a patient reveals an asymmetric 4 mm red nodule at the dorsal tongue base. The patient is asymptomatic and was unaware of the finding. Biopsy of the lesion is shown. Which of the following is true regarding the diagnosis?
Select an answer:
A. Diagnosis of this entity relies heavily on immunohistochemical findings
B. Diagnosis represents reactive hyperplasia of a normal structure
C. Significant clinical follow up is recommended, since malignant transformation occurs in the majority of patients with this finding
D. This entity is more commonly found in older adults
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Authors: Timothy Isaac Miller, M.D., M.A., Maria Tretiakova, M.D., Ph.D.
Which of the following is the most likely immunohistochemical profile of the renal neoplasm shown?
Select an answer:
A. CK7+, KIT+, vimentin-, CAIX-
B. CK7+, KIT+, vimentin-, CAIX+
C. CK7+, KIT+, vimentin+, CAIX-
D. CK7-, KIT+, vimentin-, CAIX-
E. CK7-, KIT-, vimentin+, CAIX+
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