14 July 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Placenta > Exaggerated placental site

High power image of mononucleate and multinucleate intermediate trophoblasts containing abundant eosinophilic cytoplasm with hyperchromatic and irregular nuclei.

Contributed by Raavi Gupta, M.D. and Absia Jabbar, M.D.

Soft tissue > Inflammatory myofibroblastic tumor

Loosely arranged spindle cells growing in haphazardly arranged fascicles, interspersed by abundant chronic inflammatory cells (400x).

Contributed by Carina Dehner, M.D., Ph.D.

Thyroid & parathyroid > Langerhans cell histiocytosis

Thyroid gland, Langerhans cell histiocytosis: histiocytes with convoluted, folded nuclei and pale eosinophilic cytoplasm.

Contributed by Somboon Keelawat, M.D. and Jijgee Munkhdelger, M.D., Ph.D.

Appendix > Well differentiated neuroendocrine tumor

Low power image showing nested growth of tumor cells.

Contributed by Kwun Wah Wen, M.D., Ph.D.

Liver & intrahepatic bile ducts > Cirrhosis

Cut surface of a macronodular cirrhotic liver with multiple regenerative nodules.

Contributed by Anthony W.H. Chan, M.B.Ch.B.

14 April 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Skin nonmelanocytic tumor > Atypical fibroxanthoma

Cytomorphologically, lesional cells are highly bizarre and atypical, with marked pleomorphism in size and shape, abundant eosinophilic cytoplasm, occasional multinucleation and numerous mitotic figures, including atypical forms (H&E, 200x).

Contributed by Pavandeep Gill, M.D. and Phyu Aung, M.D., Ph.D.

Stomach > Fundic gland polyp

Cystically dilated glands.

Contributed by Naziheh Assarzadegan, M.D.

Appendix > Enterobius vermicularis

Higher magnification shows Enterobius eggs with 1 flattened side and 1 convex side and a double layer hyaline chitin shell.

Contributed by Eiman Adel Hasby, M.D.

Bone marrow neoplastic > Atypical chronic myeloid leukemia

Bone marrow biopsy from a patient with aCML showing markedly hypercellular bone marrow with markedly increased neutrophils and myeloid precursors and mild dysmegakarypoiesis with no increase in blasts.

Contributed by Ling Zhang, M.D.

Esophagus > Undifferentiated carcinoma

Undifferentiated carcinoma at high power. Sheets of clearly high grade cells without obvious pattern of differentiation into any given cell type.

Contributed by Rondell P. Graham, M.B.B.S.

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17 March 2020: Biweekly Image Quiz #27

You receive an appendix for microscopic examination. You note that the patient has a history of treated Crohn’s colitis and is currently hospitalized after partial colectomy. On examination, the appendiceal serosa shows scattered neutrophils without other pathologic change. What is the most likely cause of this finding?

Select an answer:

A. Acute appendicitis

B. Crohn’s disease

C. Previous surgery

D. Salpingitis

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