2 June 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Lung > Lepidic adenocarcinoma

Noninvasive lepidic adenocarcinoma (left) juxtaposed with adjacent uninvolved lung parenchyma (right). The lepidic adenocarcinoma is characterized by thickened alveolar septa lined by atypical overlapping cuboidal cells.

Contributed by Jonathan Keow, M.D., Ph.D.

Skin nonmelanocytic tumor > Trichilemmal (pilar) type cysts

High power view of epithelial lining with maturation of squamous epithelium, which lacks a granular layer (trichilemmal differentiation).

Contributed by Aaron Muhlbauer, M.D. and Jodi Speiser, M.D.

Skin nontumor > Granuloma annulare

Palisaded granuloma annulare. Arm of a 50 year old woman.

Contributed by Stephen Somach, M.D.

Vulva, vagina & female urethra > Smooth muscle tumors

Leiomyosarcoma of the vulva, morphologically low grade, with moderately atypical, round to cigar shaped nuclei with focally prominent nucleoli (400x). Mitoses are rare (1 – 2 per 10 high power fields) and necrosis is absent.

Contributed by David B. Chapel, M.D.

Penis & scrotum > Cutaneous verruciform xanthoma

A low power view shows papillary / verrucous epithelial hyperplasia with band-like plasma cell infiltrate in the scrotum.

Contributed by Liwei Jia, M.D., Ph.D.

Autopsy & forensics > Blunt force injuries

Anterior cranial base fractures (yellow arrows).

Contributed by Lorenzo Gitto, M.D., Robert Stoppacher, M.D., Serenella Serinelli M.D., Ponni Arunkumar, M.D. and Luigi Bonaccorso, M.D.

24 March 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Breast > Filariasis

Classic “double barrel” uterus of the adult female worm (Wuchereria bancrofti) with eggs and developing larvae (microfilariae) in a lymph node (H&E, 10x).

Contributed by Bobbi Pritt, M.D.

Stains & molecular markers > Carbonic anhydrase IX

Diffuse circumferential membranous staining in clear cell RCC.

Contributed by Nick Baniak, M.D.

Stomach > MALT lymphoma

Infiltration and distortion of epithelial structures by aggregates of (usually 3 or more) neoplastic lymphoid cells.

Contributed by Kwun Wah Wen, M.D., Ph.D.

Testis & epididymis > Sex cord-stromal tumors > Leydig cell

Leydig cell tumor with sheets of polygonal cells with eosinophilic cytoplasm (H&E stain; 10x magnification).

Contributed by Manju Aron, M.D.

Autopsy & forensics > Therapy related deaths

Autopsy image of a percutaneous biliary catheter in the portal vein. The biliary drain placement was performed to relieve a biliary stricture but the catheter was placed in the portal vein adjacent to the targeted bile duct resulting in hemoperitoneum. The end of the catheter was cut during removal of the liver as this was an unexpected finding at autopsy.

Contributed by Mark A. Giffen, Jr., D.O.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

10 February 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Breast > Sparganosis

Host reaction of rimming chronic inflammation and dense fibrosis around parasite (H&E, 4x)

Contributed by Bobbi Pritt, M.D.

CNS tumor > Pituitary adenoma

Sheet-like proliferation of monomorphous cells. Absence of acinar architecture. Frozen section, 20x.

Contributed by Michael Punsoni, M.D.

CNS tumor > Medulloblastoma, SHH activated

Nodular desmoplastic medulloblastoma, SHH activated. High power H&E shows sheets of undifferentiated cells with scattered mitotic figures and apoptotic bodies. Focal anaplastic features are present (cell wrapping, center of image).

Contributed by John DeWitt, M.D., Ph.D.

Kidney tumor > Adult cystic nephroma

Multiple thin walled cysts with smooth lining.

Contributed by Bonnie Choy, M.D.

Autopsy & forensics > Forensic entomology

The irregular, superficial surface erosion of the skin, usually orange-pink to yellow in color and the absence of hemorrhage is typical of postmortem ant feeding artifact.

Contributed by Priya Banerjee, M.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

20 January 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Acute mastitis / abscess

Core needle biopsy from a 28 year old lactating woman. A dense inflammatory infiltrate is shown on the left, obscuring underlying breast parenchyma.

Contributed by Kristen E. Muller, D.O.

Prostate specific antigen (PSA)

PSA is focally positive, which is common in more poorly differentiated prostatic adenocarcinoma. Lung adenocarcinoma will not be positive for PSA, so this confirms metastatic prostatic adenocarcinoma. Of note, this patient had a clinical history of a prostatic adenocarcinoma.

Contributed by Heather I-Hsuan Chen-Yost, M.D.

Fibromatosis / fasciitis-like

Papillary thyroid carcinoma with fibromatosis / fasciitis-like stroma: myofibroblastic proliferation within collagenous stromal tissue.

Contributed by Ayana Suzuki, C.T.

Gunshot wounds

Soot deposition, searing of the skin and contusion surrounding the central defect.

Contributed by Lorenzo Gitto, M.D. and Robert Stoppacher, M.D.

How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 61 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.