5 May 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Bone & joints > Chondrosarcoma (primary, secondary, periosteal)

There is obvious nuclear atypia and pleomorphism but the background is distinctly chondroid.

Contributed by Shadi Qasem, M.D.

Bone marrow neoplastic > Myeloid / lymphoid neoplasms with eosinophilia and gene rearrangement > PCM1-JAK2

Bone marrow clot showing large, abnormal aggregate of early erythroid precursors. Also note dysplastic megakaryocytes (H&E stain, 200x).

Contributed by Zeba N. Singh, M.B.B.S., M.D.

Lymphoma & related disorders > Indolent T lymphoproliferative disease of the GI tract

Majority of T cells in the infiltrate are CD8 positive.

Contributed by Anamarija M. Perry, M.D.

Uterus > Leiomyoma-general > FH deficient leiomyoma

Spindle or epithelioid cells with ovoid nuclei and prominent eosinophilic nucleoli surrounded by perinucleolar halos.

Contributed by Sabrina Croce, M.D., Ph.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 59 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

31 March 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Lymphoma & related disorders > Aggressive NK cell leukemia

Trephine bone marrow biopsy showing an interstitial neoplastic infiltrate at high power, with moderate cytoplasm, irregular nuclear contours and prominent nucleoli.

Contributed by Siba El Hussein, M.D. and Joseph Khoury, M.D.

Soft tissue > Myxoinflammatory fibroblastic sarcoma

Low power magnification shows a lobulated soft tissue tumor with mixed fibrous and myxoid areas located within subcutaneous tissue.

Contributed by David Suster, M.D.

Stains & molecular markers > DUX4

CIC-DUX4 fusion tumor (DUX4, 10x), involving soft tissue of flank.

Contributed by Bradford Siegele, M.D., J.D.

Skin nontumor > Atrophic papulosis

Superficial and deep perivascular and periadnexal lymphocytic infiltrate (H&E, 40x).

Contributed by Kiran Motaparthi, M.D.

Bone & joints > Ganglion

Myxoid changes (gray-blue areas) are visible in the ganglion wall on the right. The remaining wall is composed of dense pink collagenous stroma. The lining of the wall does not show epithelial cells.

Contributed by Serenella Serinelli, M.D., Ph.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

17 March 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Skin nontumor > Warts (verrucae)

Hyperkeratosis, papillomatosis, hypergranulosis, koilocytosis and inward bending of rete ridges at borders of lesion. Dermal papillae show dilated capillaries.

Contributed by Heba Ahmed Abdelkader, M.D.

Small intestine & ampulla > Lymphangioma

Scanning magnification shows the dilated lymphatics in the submucosa of the small intestine (H&E, 2x).

Contributed by Haider A. Mejbel, M.D.

Stomach > Pyloric gland adenoma

High power view of PGA showing small tubular glands with low cuboidal epithelium and bland nuclei.

Contributed by Supriya Srivastava M.D., Ph.D.

Bone & joints > Adamantinoma

Anastomosing thin trabeculae of mildly atypical epithelioid and spindled cells within fibrous stroma.

Contributed by Borislav A. Alexiev, M.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

2 December 2020: Images of the Week

Here are just a few of this week’s new images from our free, online textbook:

Low grade intraosseous (central) osteosarcoma

Cellular fascicles of spindle cells with mild nuclear atypia in a fibrosclerotic stroma.

Contributed by Borislav A. Alexiev, M.D.

AML with inv(3)(q21.3;q26.2) or t(3;3)(q21.3;q26.2)

Bone marrow aspirate showing a hypolobated megakaryocyte, increased blasts and a pseudo-Pelger-Hüet neutrophil.

Contributed by Alexa J. Siddon, M.D.

Telecytology

Snapshot of dynamic microscopy from the pathologist end (10x objective), showing annotations and the control buttons.

Contributed by Jason A. Thomas, C.T. and Sigfred Lajara, M.D.

Liver & intrahepatic bile ducts → Viral hepatitis → COVID-19

Occasional cases (15%) have sinusoidal microthrombi (600x).

Contributed by Stephen M. Lagana, M.D.

How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 61 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.