12 January 2022: “Ending Cancer As We Know It”

On the 50th anniversary of the National Cancer Act of 1971, we are highlighting videos discussing President Biden’s goal of “ending cancer as we know it”.

First is this video from Dr. Ned Sharpless, Director of the National Cancer Institute:

Our “Curing Cancer Network” group is focused on substantially reducing cancer deaths.

What are your ideas for substantially reducing cancer deaths? Post them in the comments below or email Dr. Pernick at Nat@PathologyOutlines.com.

5 March 2021: Weekly Roundup #39

This is what’s new on PathologyOutlines.com:

1. Pathologist Jobs Report – Q4 2020

The pathologist jobs report for the fourth quarter of 2020 is now available. It begins:

“For this quarter, there were 240 job postings at PathologyOutlines.com for full time or part time Pathologists, which form the basis for the statistics below. This is a 20.6% increase from the 199 job postings in the fourth quarter of 2018 (click here and note that data is not available for the 4rd quarter of 2019 as we were installing a new database). We excluded postings that were only for locum, Ph.D., residency, fellowship or non-Pathologist positions. Of the 240 postings, 223 were for 1 position, 11 were for 2 positions and 6 were for an unspecified number of positions greater than 1.”

All job reports are accessible from the Jobs page.

2. Website Traffic

We had a record number of sessions (visits) last month (an average of 51,817/day), as well as a record numbers of total sessions (1,450,867) and page views (3,126,867). Thanks for your support!

3. The American Code Against Cancer

Dr. Pernick has proposed The American Code Against Cancer, resembling the European Code, listing behavioral changes to help reduce annual U.S. cancer deaths from 600,000 to 100,000. Email your comments to Nat@PathologyOutlines.com.

19 February 2021: Weekly Roundup #37

This is what’s new on PathologyOutlines.com:

1. Promotional Email Contest Winner

Dr. Anne Hoorens from the Dept. of Pathology at Ghent University Hospital in Belgium has won the Q4 2020 PathologyOutlines.com Promotional Email Contest! For simply opening up PathologyOutlines.com promotional emails, Dr. Hoorens has won a $50 Amazon gift card.

If you’d like a chance at winning, click here for sign up information and terms.

2. Grant Applications

Dr. Nat Pernick is accepting applications for a single, nonrenewable grant of up to $10,000 for a research study of possible intermediate states for glioblastoma detectable by molecular methods. See here for more details.

3. Top PathologyOutlines.com Authors in 2020

Congratulations to our top 25 most prolific authors in 2020! If you’re interested in becoming an author, please review our guidelines and your qualifications here.

4. Curing Cancer

Dr. Pernick is seeking collaborators to help implement his strategic plan for curing cancer, which has been posted on his blog. It has now been 50 years since the war on cancer was announced by President Richard M. Nixon in 1971. It is time to assess what needs to be done and start to do it. If this interests you, please email Dr. Pernick at NatPernick@gmail.com.

5 February 2021: Weekly Roundup #35

This is what’s new on PathologyOutlines.com:

1. What’s New in Gynecologic Pathology

Our What’s New in Gynecologic Pathology Part 1 e-newsletter will summarize important changes in the vulva, cervix and uterus based on the 5th edition of WHO Tumours of Female Reproductive Organs, published last year. Click here to subscribe to this great newsletter, which comes out 2 – 4 times per year.

2. New Resident / Fellow Advisory Board Appointments

We have appointed new members of our Resident / Fellow Advisory Board as of January 2021:

3. New COVID-19 Article

Our COVID-19 library (click on “Libraries” in our site navigation, then select COVID-19 Library) has a new article, Operation Moonshot rapid tests for COVID-19 barely work, posted 4 February 2021.

4. Curing Cancer Blog

Dr. Pernick has published a new essay in his blog, Curing Cancer – Part 7 – Random chronic stress / bad luck as a major cause of cancer.

Key concepts discussed are: (1) random chronic stress / bad luck is a major cause of cancer at some sites; (2) cancer often develops through rare bursts of activity in cells and their networks, not in a gradual, step-wide manner; (3) cancers due to random chronic stress may have better survival and other clinical differences compared to cancers due to traditional risk factors and (4) due to the presence of random chronic stress, cancer will always be with us; although we can prevent some cases, we can detect it earlier and we can treat it more effectively.

Click here to read parts 1 – 6 of this series and to follow Dr. Pernick’s blog.

15 January 2021: Weekly Roundup #32

This is what’s new on PathologyOutlines.com:

1. Dr. Pernick’s Curing Cancer Blog

Dr. Pernick has written his fourth essay about curing cancer based on complexity theory. Click here for a PDF download or read the essay here. You can also follow his blog for regular updates directly to your inbox. In part 3, he summarized recommendations on curative treatment for advanced adult cancers with a poor prognosis, such as lung and pancreatic cancer. In this essay, he discusses these principles of curative treatment in greater depth: network medicine, blocking multiple pathways, combinations of combinations of treatment, monitoring key networks, clinical trials and strong public health programs. He is happy to respond to comments or questions at Nat@PathologyOutlines.com.

See also Curing cancer, Part 1 – Reductionism vs. Complexity, Curing Cancer, Part 2 – Adult vs. Childhood Cancer and Curing Cancer – Part 3 – Curative cancer treatment based on complexity theory.

2. What’s New This Week Video

We have a new short video, This Week At PathologyOutlines.com, posted on our homepage and on our YouTube channel. We also have a text summary in the description box of the YouTube video if you are in a hurry.

3. New COVID-19 Article

Our COVID-19 library (click on “Libraries” in our site navigation, then select COVID-19 Library) has a new article, FDA Issues Alert Regarding SARS-CoV-2 Viral Mutation, posted 8 January 2021.

4. Case #499

Case #499 was posted on January 14. You can also sign up for our monthly case newsletters and more here.

5. Author Payment

As of September 2020, we stopped paying authors with 3+ topics, although we will honor payment to authors who wrote 3+ topics before the end of 2020. Please give us time to contact you about payment or feel free to contact us by 31 January 2021 at Authors@PathologyOutlines.com if you believe you are owed money for author topics.

6. Website Traffic in 2020

Despite the COVID-19 pandemic, our website traffic was still up 3.5% in 2020 compared to 2019. Average traffic in 2020 was 40,628 visits / day, with over 32 million pageviews sitewide. As always thank you for your support and please contact us at CommentsPathOut@gmail.com with any suggestions on how to improve the website.

8 January 2021: Weekly Roundup #31

Happy New Year! This is what’s new on PathologyOutlines.com:

1. Dr. Pernick’s Curing Cancer Blog

Dr. Pernick’s next short essay in his “Curing Cancer” blog series can be read here. It outlines his recommendations for curative treatment for advanced adult cancers with a poor prognosis, such as lung and pancreatic cancer. The main point is that advanced cancer is not just due to driver mutations but also to systemic network changes that will not revert to normal if the tumor is excised or destroyed. Email any comments or questions to Nat@PathologyOutlines.com.

See also Curing cancer, Part 1 – Reductionism vs. Complexity and Curing Cancer, Part 2 – Adult vs. Childhood Cancer.

2. Jobs Graph

We have a new Jobs graph that tracks the total number of jobs from January 2017 to date. Use the slide bar to focus on a particular time period.

3. Jobs Page Features

Below the blue box on our Jobs page you can find regularly updated lists of Pathology chairs and Residency directors. Use the Comment feature in the Header to tell us of any needed updates.

4. Website Navigation

To navigate more quickly, use the Breadcrumbs at the top and bottom of each topic page. You can also go back to the main chapter or our Home page.

5. E-blast Security

To improve security, we have added a “Double opt-in” feature for our E-blasts. This means that after you sign up, you will receive an email with a link to confirm that you really did make the changes. We have several hundred requests “in limbo”, so if you are not getting the E-blasts you signed up for, please subscribe again and confirm with the follow up email.

31 March 2020: “Active Surveillance”

Here is an oil print interpretation of prostatic adenocarcinoma, painted by Eugene Maurakis:

Oil on canvas (30×40″), Eugene G. Maurakis, Ph.D.

A message from Eugene:

“Interpretation of Gleason 3+3 prostate cancer from histological section of prostate stained with hematoxylin and eosin based on Iczkowski KA. 2020. Grading Gleason. Many thanks to Drs. Iczkowski and Pernick, and E. Thomas for permission to use their image.

In December 2019, I was diagnosed with the lowest grade of prostate cancer, which may not progress to a more aggressive disease.* My intent of this post is solely to heighten men’s awareness that prostate cancer can occur as one ages, even if you maintain a healthy lifestyle, stay active, and eat close to the Earth. At first, I was hesitant whether I should post such a personal story through this painting as I don’t want anyone to tell me “I’m sorry.” I am positive and upbeat, and living life to the fullest. Knowledge is power.”

*Garisto, J.D. and L. Klotz. 2017. Active Surveillance for Prostate Cancer: How to Do It Right. Oncology 31(5):333-340. There has been a nearly 70% increase in new prostate cancer cases, mostly classified as low risk, that have been diagnosed in early stages as a consequence of prostate-specific antigen (PSA) screening. Data regarding the natural history of this disease confirm the clinical insignificance of low-grade prostate cancer, which is associated with scant or no metastatic dissemination. Active surveillance is a conservative management approach, conducted for those patients with “low-risk” or “favorable-risk” disease, which avoids long-term adverse effects on the patient’s quality of life.

For more information on prostate cancer and the different grades of the disease, see these two 2019 and 2020 articles: