7 April 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Cervix > HSIL / CIN II / CIN III

At high magnification, HSIL / CIN III lacks maturation (400x).

Contributed by Khaled J. Alkhateeb, M.B.B.S.

Ovary > Fibroma

Ovarian fibroma: the cut surface reveals a dense white mass within the ovary (left); outer surface of the fibroma is smooth and lightly vascularized (right).

Contributed by Rex Bentley, M.D.

Testis & epididymis > Adult granulosa cell

Low power view of numerous small uniform spaces (microfollicles) with hyalinized basement membrane material (Call-Exner bodies).

Contributed by Kristine M. Cornejo, M.D.

Microbiology & parasitology > Zygomycetes

Evaluation of fungal forms. H&E stained FFPE tissue showing broad pauciseptate ribbon-like hyphae in necrotic sinonasal tissue.

Contributed by Sixto M. Leal, Jr., M.D., Ph.D.

Skin nonmelanocytic tumor > Syringoma

Histologic sections showing cysts, nests and cords in a paisley or tadpole shaped pattern. No cytologic atypia or mitotic figures are seen (H&E, original magnification 100x).

Contributed by Aadil Ahmed, M.D. and Sara C. Shalin, M.D., Ph.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

3 March 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Cervix > HPV related adenocarcinoma (usual type and variants)

Invasive adenocarcinoma, pattern B (H&E stain). Early destructive invasion, in an otherwise well differentiated (pattern A) neoplasm is seen as small irregular glands with prominent inflammation and stromal desmoplasia.

Contributed by Carlos Parra-Herran, M.D.

Stains & molecular markers > HER2 colon

Score 3+, HER2 IHC: the tumor cells of this colorectal adenocarcinoma show strong circumferential membrane staining (200x).

Contributed by Roula Katerji, M.D. and Aaron R. Huber, D.O.

Stains & molecular markers > Pan-TRK (EPR17341) [NTRK]

Infantile fibrosarcoma spectrum of tumors – neonate at birth with a lower thigh mass harboring a TPM3-NTRK1 fusion: panTRK antibody with cytoplasmic expression (400x).

Contributed by Jessica L. Davis, M.D.

Liver & intrahepatic bile ducts > Hepatocellular carcinoma overview

Hepatectomy for hepatocellular carcinoma demonstrating large cytoplasmic hyaline eosinophilic inclusions and trabecular architecture (400x).

Contributed by Irene Y. Chen, M.D.

Small intestine & ampulla > Adenocarcinoma-small intestine

Diagnostic low magnification frozen section image showing complex glandular architecture and desmoplastic stromal reaction (H&E, 40x).

Contributed by Krutika S. Patel, M.B.B.S., M.D. and Annika L. Windon, M.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

9 February 2021: Image Quiz #49

Authors: Jennifer Pors, M.D.Lynn Hoang, M.D.

Which immunohistochemical staining profile would you expect in the cervical neoplasm depicted in this image?

Select an answer:

A. PAX8-, ER-, GATA3+, AMACR+

B. PAX8+, ER-, GATA3+, napsin A-

C. PAX8+, ER+, GATA3-, napsin A-

D. PAX8+, ER-, napsin A+, AMACR+

To sign up for our biweekly image quiz newsletters and more, visit pathologyoutlines.com/subscribe.html.

27 January 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Microglandular hyperplasia

High power view showing columnar epithelial cells with subnuclear and supranuclear vacuoles, bland nuclei and mucinous cytoplasm, associated with reserve cell hyperplasia; luminal neutrophils in some glands.

Contributed by Gulisa Turashvili, M.D., Ph.D.

Epithelioid hemangioendothelioma

Tumor is comprised of cords, strands and small nests of large endothelial cells with abundant eosinophilic cytoplasm embedded in a myxohyaline stroma.

Contributed by Iva Brčić, M.D., Ph.D. and Bernadette Liegl-Atzwanger, M.D.

Sertoli cell tumor, NOS

Testicular Sertoli cell tumor, NOS (H&E), low magnification, back to back cords of bland, clear cells with abundant cytoplasm.

Contributed by Thomas Ulbright, M.D.

Coombs test / DAT

The results of a patient’s direct antiglobulin (DAT) / Coombs test.

Contributed by Thomas J. Gniadek, M.D., Ph.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 61 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

5 May 2020: Biweekly Image Quiz #30

Author: Natalia Buza, M.D.

Which of the following statements is true about this endocervical lesion?

Select an answer:

A. Presence of any mitotic activity indicates malignancy

B. Presence of heterologous mesenchymal elements indicates malignancy

C. Rarely, such lesions may harbor in situ or invasive malignancy

D. Such lesions are most common in children and adolescents

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