2 February 2022: Best Authors of 2021

Congratulations to the winners of the PathologyOutlines.com 2021 Best Author Award! This was a very competitive award and we greatly appreciate the contributions of those named below in addition to those of our other diligent authors in 2021, all of whom you can view here. You can view the winners from past years here.

Here are the 2021 winners:

  1. Oral cavity & oropharynx > Oropharynx squamous cell carcinoma > HPV negative: Written by Katherine Hulme, M.B.Ch.B. and Ruta Gupta, M.D. 
  2. Uterus > Stromal tumors > Low grade endometrial stromal sarcoma: Written by Elizabeth Kertowidjojo, M.D., Ph.D., M.P.H. and Lora Hedrick Ellenson, M.D. 
  3. Breast > Papillary carcinoma > Solid papillary carcinoma: Written by Sofia Lérias, M.D. and Melinda Lerwill, M.D. 
  4. CNS tumor > Other tumors > Hemangioblastoma: Written by Rebecca Yoda, M.D. and P.J. Cimino, M.D., Ph.D. 
  5. Liver > Other malignancies > Hepatoblastoma: Written by Rui Caetano Oliveira, M.D. and Maria Augusta Cipriano, M.D. 

If you are interested in being an author for PathologyOutlines.com, please send your CV and a list of topics or chapters you are interested in writing / reviewing to our author coordinators at Authors@PathologyOutlines.com. You may also review your qualifications here.

28 July 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Breast > Fibromatosis

Spindle cells appear bland with no mitotic activity.

Contributed by Carissa LaBoy, M.D.

CNS tumor > Diffuse leptomeningeal glioneuronal tumor

Tumor cells with a low grade, monomorphic appearance showing perinuclear haloes, reminiscent of oligodendroglioma (200x overall magnification).

Contributed by Katherine Schwetye, M.D., Ph.D.

Kidney nontumor > Congenital nephrotic syndrome

Prominent cystically dilated proximal and distal tubules with an attenuated epithelium (periodic acid-Schiff stain).

Contributed by Chunlai Zuo, M.D., M.S. and Jonathan E. Zuckerman, M.D., Ph.D.

Ovary > Serous cystadenoma / adenofibroma

Large serous cystadenoma with localized (less than 10% of sampled cyst wall) epithelial proliferation. No complex papillary growth is seen (H&E, 100x).

Contributed by Catherine J. Roe, M.D. and Krisztina Hanley, M.D.

Stains & CD markers > Special AT-rich sequence-binding protein 2 (SATB2)

Colon neuroendocrine tumor, well differentiated (SATB2).

Contributed by Sepideh Besharati, M.D.

7 July 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

CNS tumor > Papillary craniopharyngioma

Classic low power cauliflower-like configuration with smooth borders.

Contributed by Nelli S. Lakis M.D., M.Sc.

Nasal cavity, paranasal sinuses, nasopharynx > Sinonasal undifferentiated carcinoma

Sheets of undifferentiated malignant epithelial cells with vesicular nuclear chromatin and prominent nucleoli.

Contributed by Bin Xu, M.D., Ph.D. and Abeer Salama, M.D.

Placenta > Choriocarcinoma

Intraplacental choriocarcinoma showing atypical syncytiotrophoblast, cytotrophoblast and intermediate trophoblast adjacent to uninvolved chorionic villi (H&E, 200x).

Contributed by Tatyana Zinger, D.O.

Small intestine & ampulla > Heterotopic gastric mucosa

Polypoid lesion predominantly lined by gastric foveolar epithelium and small intestinal epithelium on the left side.

Contributed by Khalid Amin, M.D.

Liver & intrahepatic bile ducts > Hepatocellular adenoma

HNF1A mutated hepatocellular adenoma: low power view showing well defined border between the lesion (right) and background liver (left).

Contributed by Monica Abdelmalak, M.D.

28 April 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Ovary > Mucinous borderline tumor / atypical proliferative mucinous tumor

Multiloculated cyst with mucinous contents and smooth external surface.

Contributed by Russell Vang, M.D.

Placenta > Decidual arteriopathy

Advanced decidual arteriopathy with fibrinoid necrosis. Arteries are distended and show endothelial injury (detachment from the wall, arrow) and fibrinoid necrosis of the media (*). 200x original magnification.

Contributed by Jonathan L. Hecht, M.D., Ph.D.

Breast > Tubular adenoma

Eosinophilic secretions present in the lumens of some of the tubules (H&E, 20x magnification).

Contributed by Joshua J.X. Li, M.B.Ch.B. and Gary M. Tse, M.B.B.S.

Breast > Metaplastic carcinoma

Moderate to markedly cytologic atypia and frequent mitosis (200x).

Contributed by Huina Zhang, M.D., Ph.D.

Placenta > Maternal vascular malperfusion

Infarction (fresh): infarcts are typically pyramidal shape and involve the maternal floor of the placenta. Older infarcts are white, while more recent infarcts are red / heterogeneous in the fresh state.

Contributed by Jonathan L. Hecht, M.D., Ph.D.

Salivary glands > Acinic cell carcinoma

Parotid gland FNA of acinic cell carcinoma. The neoplastic cells are large with abundant finely vacuolated to granular cytoplasm (Diff-Quik).

Contributed by Arash H. Lahouti, M.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 59 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

21 April 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Kidney nontumor > Acute pyelonephritis

Acute inflammation / pus in renal calyx.

Contributed by Jian-Hua Qiao, M.D.

Liver & intrahepatic bile ducts > Combined hepatocellular carcinoma-cholangiocarcinoma

Unequivocal cholangiocytic (red arrow) and hepatocytic (blue arrow) areas of cell differentiation. The hepatocytic area shows tumor cells organized in trabeculae (H&E 100x).

Contributed by Aurélie Beaufrère, M.D.

Bone marrow neoplastic > Myeloid neoplasms with germline predisposition and other organ dysfunction with GATA2 mutation

Bone marrow core biopsy of the same patient shows megakaryocytic dysplasia (small, hypolobated) (H&E, 40x).

Contributed by Wei Wang, M.D., Ph.D.

CNS tumor > Pituicytoma

Nuclear expression of TTF1 is ubiquitous.

Contributed by Federico Roncaroli, M.D.

Muscle & peripheral nerve nontumor > Immune mediated necrotizing myopathy

Thigh muscle from a 49 year old woman with progressive proximal weakness and creatine kinase in the 7,000s. Histology shows a pauci-inflammatory IMNM. The necrotic fibers are randomly distributed and temporally heterogeneous. There is also moderate fiber size variation and frequent internalized nuclei, suggesting that myofiber damage has been going on for a while (H&E, 20x).

Contributed by Chunyu “Hunter” Cai, M.D., Ph.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 59 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

10 February 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Breast > Sparganosis

Host reaction of rimming chronic inflammation and dense fibrosis around parasite (H&E, 4x)

Contributed by Bobbi Pritt, M.D.

CNS tumor > Pituitary adenoma

Sheet-like proliferation of monomorphous cells. Absence of acinar architecture. Frozen section, 20x.

Contributed by Michael Punsoni, M.D.

CNS tumor > Medulloblastoma, SHH activated

Nodular desmoplastic medulloblastoma, SHH activated. High power H&E shows sheets of undifferentiated cells with scattered mitotic figures and apoptotic bodies. Focal anaplastic features are present (cell wrapping, center of image).

Contributed by John DeWitt, M.D., Ph.D.

Kidney tumor > Adult cystic nephroma

Multiple thin walled cysts with smooth lining.

Contributed by Bonnie Choy, M.D.

Autopsy & forensics > Forensic entomology

The irregular, superficial surface erosion of the skin, usually orange-pink to yellow in color and the absence of hemorrhage is typical of postmortem ant feeding artifact.

Contributed by Priya Banerjee, M.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.