2 June 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Lung > Lepidic adenocarcinoma

Noninvasive lepidic adenocarcinoma (left) juxtaposed with adjacent uninvolved lung parenchyma (right). The lepidic adenocarcinoma is characterized by thickened alveolar septa lined by atypical overlapping cuboidal cells.

Contributed by Jonathan Keow, M.D., Ph.D.

Skin nonmelanocytic tumor > Trichilemmal (pilar) type cysts

High power view of epithelial lining with maturation of squamous epithelium, which lacks a granular layer (trichilemmal differentiation).

Contributed by Aaron Muhlbauer, M.D. and Jodi Speiser, M.D.

Skin nontumor > Granuloma annulare

Palisaded granuloma annulare. Arm of a 50 year old woman.

Contributed by Stephen Somach, M.D.

Vulva, vagina & female urethra > Smooth muscle tumors

Leiomyosarcoma of the vulva, morphologically low grade, with moderately atypical, round to cigar shaped nuclei with focally prominent nucleoli (400x). Mitoses are rare (1 – 2 per 10 high power fields) and necrosis is absent.

Contributed by David B. Chapel, M.D.

Penis & scrotum > Cutaneous verruciform xanthoma

A low power view shows papillary / verrucous epithelial hyperplasia with band-like plasma cell infiltrate in the scrotum.

Contributed by Liwei Jia, M.D., Ph.D.

Autopsy & forensics > Blunt force injuries

Anterior cranial base fractures (yellow arrows).

Contributed by Lorenzo Gitto, M.D., Robert Stoppacher, M.D., Serenella Serinelli M.D., Ponni Arunkumar, M.D. and Luigi Bonaccorso, M.D.

10 March 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Liver & intrahepatic bile ducts > Chronic antibody mediated rejection

H&E stained section at 20x demonstrating a predominantly mononuclear portal inflammatory infiltrate with spillage into adjacent hepatic parenchyma.

Contributed by Mohamed El Hag, M.D., M.S.

Liver & intrahepatic bile ducts > Hepatoblastoma

Hepatoblastoma, SCUD pattern, with siderophages (secondary to treatment) (H&E 200x).

Contributed by Rui Caetano Oliveira, M.D. and Maria Augusta Cipriano, M.D.

Lung > Minimally invasive adenocarcinoma

Noninvasive lepidic adenocarcinoma (left) juxtaposed with adjacent uninvolved lung parenchyma (right). The lepidic adenocarcinoma is characterized by thickened alveolar septa lined by atypical overlapping cuboidal cells.

Contributed by Jonathan Keow, M.D., Ph.D.

Ovary > Serous tumors > Serous borderline tumor

Inked cyst wall lined by exuberant solid growth of papillary grape-like excrescences.

Contributed by Aarti Sharma, M.D. and Ricardo R. Lastra, M.D.

Placenta > Complete hydatidiform mole

Haphazard circumferential proliferation of cytotrophoblasts and syncytiotrophoblasts is seen around a club shaped villus in this image of a complete mole. Some of the nuclei show considerable atypia and mitoses.

Contributed by Rachelle Mendoza, M.D. and Raavi Gupta, M.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

12 January 2021: Image Quiz #47

Author: Jian-Hua Qiao, M.D.

An 80 year old Caucasian woman had a thyroid mass and a 1 cm pulmonary lesion. CT guided transthoracic needle biopsy was performed to rule out metastatic tumor. Microscopic examination of core needle biopsy tissue reveals the following lesion. What is your diagnosis?

Select an answer:

A. Metastatic thyroid papillary carcinoma

B. Minute pulmonary meningothelial-like nodule

C. Pulmonary carcinoid tumor

D. Pulmonary meningioma

E. Pulmonary paraganglioma

To sign up for our biweekly image quiz newsletters and more, visit pathologyoutlines.com/subscribe.html.

9 December 2020: Images of the Week

Here is a selection of new images from our free, online textbook:

Adenomyoepithelial adenosis

Haphazardly arranged glands with bland epithelium and prominent myoepithelium with clear cytoplasm (H&E, 20x).

Contributed by Julie M. Jorns, M.D.

CD70

Immunohistochemical double staining demonstrating expression of CD34 (brown) by myeloid blasts and CD70 (red) by interstitial immune cells.

Contributed by Christian Schürch, M.D., Ph.D.

Indeterminate cell histiocytosis

Skin biopsy showing histiocytoid cells with eosinophilic cytoplasm and grooved, reniform nuclei in the dermis in indeterminate cell histiocytosis, 400x.

Contributed by Ryanne A. Brown, M.D., M.B.A.

Atypical carcinoid

Pulmonary atypical carcinoid tumor showing salt and pepper chromatin with inconspicuous nucleoli (400x).

Contributed by Philippe Joubert, M.D., Ph.D.

Buschke-Löwenstein tumor

Low magnification view of resection sample shows arborizing papillary architecture and maturing squamous surface epithelium.

Contributed by Lewis A. Hassell, M.D. (source: Juan Rosai Slide Collection)

How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 61 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.


4 December 2020: Weekly Roundup #28


This is what’s new on PathologyOutlines.com this week:

1. COVID-19 Library

Our COVID-19 library now lists 4 topics from 2020:

2. New COVID-19 Article

We also have linked an obituary from The New York Times in our COVID-19 library: “Dr. Mary Fowkes, 66, Dies; Helped Science Understand the Pandemic.”

3. About PathologyOutlines.com

In response to some questions, we have started posting a history of our website on our About Us page, and you can read a brief story of our website on this page.

28 August 2020: Weekly Roundup #22

Here’s what’s new on PathologyOutlines.com this week:

1. Chapter Mergers

We have now merged the Lung nontumor and tumor chapters into a single Lung chapter. Other recent chapter mergers include Colon, Liver and Breast.

2. Promotional Email Contest Winner #2

Christina Arnold, who works at the University of Colorado in Denver, has won the second PathologyOutlines.com Promotional Email Contest! For simply opening up PathologyOutlines.com email blasts, Christina has won a $50 Amazon gift card.

If you’d like a chance at winning, click here for sign up information and terms.

3. COVID-19 Library 

Visit our COVID-19 Library and its News section to stay up to date on what pathologists need to know.

4. COVID-19 Diagnostic Test

The FDA has issued an emergency use authorization for the SalivaDirect COVID-19 diagnostic test, developed by the Yale School of Public Health (ASH Clinical News, posted 21 August 2020). See also Yale Medicine.