4 August 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Lymphoma & related disorders > Prolymphocytic leukemia

Diffuse marrow involvement by medium to large sized cells with prominent nucleoli (200x, H&E).

Contributed by Richard K. Wood, M.D. and Dietrich Werner, M.D.

Ovary > Thecoma

Well circumscribed, firm, yellow-tan mass.

Contributed by Victoria Collins, M.D. and Tamara Kalir, M.D., Ph.D.

Prostate gland & seminal vesicles > Anatomy & histology

Here, the central zone cells are hyperplastic. Despite the cribriform structure, the bland nuclei rule out intraepithelial neoplasia or cribriform cancer. Also note the surrounding dense stroma of the central zone.

Contributed by Kenneth A. Iczkowski, M.D.

Prostate gland & seminal vesicles > Malakoplakia

Michaelis-Gutmann bodies highlighted by arrows.

Contributed by Theodorus van der Kwast, M.D., Ph.D.

Small intestine & ampulla > GIST

Small intestinal GIST with skeinoid fibers.

Contributed by Shefali Chopra, M.D.

31 March 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Lymphoma & related disorders > Aggressive NK cell leukemia

Trephine bone marrow biopsy showing an interstitial neoplastic infiltrate at high power, with moderate cytoplasm, irregular nuclear contours and prominent nucleoli.

Contributed by Siba El Hussein, M.D. and Joseph Khoury, M.D.

Soft tissue > Myxoinflammatory fibroblastic sarcoma

Low power magnification shows a lobulated soft tissue tumor with mixed fibrous and myxoid areas located within subcutaneous tissue.

Contributed by David Suster, M.D.

Stains & molecular markers > DUX4

CIC-DUX4 fusion tumor (DUX4, 10x), involving soft tissue of flank.

Contributed by Bradford Siegele, M.D., J.D.

Skin nontumor > Atrophic papulosis

Superficial and deep perivascular and periadnexal lymphocytic infiltrate (H&E, 40x).

Contributed by Kiran Motaparthi, M.D.

Bone & joints > Ganglion

Myxoid changes (gray-blue areas) are visible in the ganglion wall on the right. The remaining wall is composed of dense pink collagenous stroma. The lining of the wall does not show epithelial cells.

Contributed by Serenella Serinelli, M.D., Ph.D.

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How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

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16 December 2020: Micro Images of the Week

Here is a selection of new images from our free, online textbook:

Adenosis

Expanded terminal duct lobular unit and adjacent (upper left) normal size terminal duct lobular unit (H&E, 4X).

Contributed by Julie M. Jorns, M.D.

Congenital mesoblastic nephroma

Tumor composed of intersecting fascicles of spindle cells.

Contributed by Ellen D’Hooghe, M.D. and Gordan M. Vujanic, M.D., Ph.D.

Large B cell lymphomas: ALK+ LBCL

ALK positive large B cell lymphoma with ALK positivity (bone marrow, IHC, 200x).

Contributed by Marie Therese Manipadam, M.B.B.S., M.D.

Molecular aspects of pancreatic cancer

Site: pancreatic head. Procedure: Whipple resection. Diagnosis: medullary pancreatic ductal adenocarcinoma. Histologic finding: neoplastic cells with syncytial growth and without gland formation (hematoxylin eosin, original magnification 10x). Molecular findings: microsatellite instability is very common in the case of medullary histology.

Contributed by Claudio Luchini, M.D., Ph.D.

Chronic sialadenitis / sialolithiasis

40 year old man with submandibular pain; chronic inflammation with acinar atrophy and fibrosis (10x).

Contributed by James S. Lewis, M.D.

How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 61 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

23 September 2020: Image Quiz #39

Authors: Jayalakshmi Balakrishna, M.D., Elaine S. Jaffe, M.D.

A 20 year old man presents with an enlarged painless cervical lymph node he has had for the past 6 months. An excisional biopsy is shown in the image. The neoplastic cells are positive for CD45 and CD20 and are negative for CD15 and CD30. Which of the following is true about this entity?

Select an answer:

A. Background is rich in cytotoxic T cells

B. Background lacks small B cells

C. Neoplastic cells are OCT2 positive

D. Neoplastic cells are PAX5 negative

See the answer

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