6 September 2022: Image Quiz #90

Authors: Absia Jabbar, M.D., Sonali Lanjewar, M.D., M.B.B.S., Raavi Gupta, M.D.

Exaggerated placental site (shown in the image below) is characterized by which of the following features?

Select an answer:

A. Absence of villi

B. Presence of necrosis and mitoses

C. Proliferation of chorionic type intermediate trophoblasts with invasion of myometrium

D. Proliferation of implantation type intermediate trophoblasts with invasion of myometrium

See the answer

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14 July 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Placenta > Exaggerated placental site

High power image of mononucleate and multinucleate intermediate trophoblasts containing abundant eosinophilic cytoplasm with hyperchromatic and irregular nuclei.

Contributed by Raavi Gupta, M.D. and Absia Jabbar, M.D.

Soft tissue > Inflammatory myofibroblastic tumor

Loosely arranged spindle cells growing in haphazardly arranged fascicles, interspersed by abundant chronic inflammatory cells (400x).

Contributed by Carina Dehner, M.D., Ph.D.

Thyroid & parathyroid > Langerhans cell histiocytosis

Thyroid gland, Langerhans cell histiocytosis: histiocytes with convoluted, folded nuclei and pale eosinophilic cytoplasm.

Contributed by Somboon Keelawat, M.D. and Jijgee Munkhdelger, M.D., Ph.D.

Appendix > Well differentiated neuroendocrine tumor

Low power image showing nested growth of tumor cells.

Contributed by Kwun Wah Wen, M.D., Ph.D.

Liver & intrahepatic bile ducts > Cirrhosis

Cut surface of a macronodular cirrhotic liver with multiple regenerative nodules.

Contributed by Anthony W.H. Chan, M.B.Ch.B.

7 July 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

CNS tumor > Papillary craniopharyngioma

Classic low power cauliflower-like configuration with smooth borders.

Contributed by Nelli S. Lakis M.D., M.Sc.

Nasal cavity, paranasal sinuses, nasopharynx > Sinonasal undifferentiated carcinoma

Sheets of undifferentiated malignant epithelial cells with vesicular nuclear chromatin and prominent nucleoli.

Contributed by Bin Xu, M.D., Ph.D. and Abeer Salama, M.D.

Placenta > Choriocarcinoma

Intraplacental choriocarcinoma showing atypical syncytiotrophoblast, cytotrophoblast and intermediate trophoblast adjacent to uninvolved chorionic villi (H&E, 200x).

Contributed by Tatyana Zinger, D.O.

Small intestine & ampulla > Heterotopic gastric mucosa

Polypoid lesion predominantly lined by gastric foveolar epithelium and small intestinal epithelium on the left side.

Contributed by Khalid Amin, M.D.

Liver & intrahepatic bile ducts > Hepatocellular adenoma

HNF1A mutated hepatocellular adenoma: low power view showing well defined border between the lesion (right) and background liver (left).

Contributed by Monica Abdelmalak, M.D.