4 August 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Lymphoma & related disorders > Prolymphocytic leukemia

Diffuse marrow involvement by medium to large sized cells with prominent nucleoli (200x, H&E).

Contributed by Richard K. Wood, M.D. and Dietrich Werner, M.D.

Ovary > Thecoma

Well circumscribed, firm, yellow-tan mass.

Contributed by Victoria Collins, M.D. and Tamara Kalir, M.D., Ph.D.

Prostate gland & seminal vesicles > Anatomy & histology

Here, the central zone cells are hyperplastic. Despite the cribriform structure, the bland nuclei rule out intraepithelial neoplasia or cribriform cancer. Also note the surrounding dense stroma of the central zone.

Contributed by Kenneth A. Iczkowski, M.D.

Prostate gland & seminal vesicles > Malakoplakia

Michaelis-Gutmann bodies highlighted by arrows.

Contributed by Theodorus van der Kwast, M.D., Ph.D.

Small intestine & ampulla > GIST

Small intestinal GIST with skeinoid fibers.

Contributed by Shefali Chopra, M.D.

30 June 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Muscle & peripheral nerve nontumor > Antisynthetase syndrome associated myositis

57 year old man with positive Jo1 antibody and interstitial lung disease. H&E shows necrotic fibers and myophagocytosis predominantly involving perifascicular fibers. The perimyisial connective tissue appears edematous and fragmented.

Contributed by Chunyu “Hunter” Cai, M.D., Ph.D.

Ovary > Clear cell carcinoma

Clear cell carcinoma with a predominant tubulocystic growth pattern.

Contributed by Gulisa Turashvili, M.D., Ph.D.

Prostate gland & seminal vesicles > Sarcomatoid carcinoma

A monophasic sarcomatoid carcinoma shows only a spindle cell component with mesenchymal appearance, without admixed carcinoma. Extensive sampling and history of prostatic adenocarcinoma, preferably with immunohistochemical (keratins, rarely PSA or other prostatic markers) evidence of epithelial differentiation, helps establish the diagnosis.

Contributed by Steven Christopher Smith, M.D., Ph.D.

Stains & molecular markers > PRAME

Positive nuclear staining for PRAME in seminiferous tubules.

Contributed by Cecilia Lezcano, M.D.

19 May 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Lymphoma & related disorders > Large B cell lymphomas-special subtypes > EBV+

Low power view showing large transformed cells admixed with small lymphocytes.

Contributed by Sudhir Perincheri, M.B.B.S., Ph.D.

Lymphoma & related disorders > PTLD-polymorphic

400x magnification image demonstrating a polymorphic lymphoid infiltrate with full maturation, ranging from small, mature lymphoid cells to intermediate to large sized immunoblastic cells. Scattered plasma cells and eosinophils are also seen.

Contributed by Daniel Cassidy, M.D. and Jennifer Chapman, M.D.

Prostate gland & seminal vesicles > Adenosis / atypical adenomatous hyperplasia

Prostate, transurethral resection, adenosis. Medium power view of crowded, closely spaced acini lined by cells with clear cytoplasm and normal size nuclei (H&E, 20x).

Contributed by Cristina Magi-Galluzzi, M.D., Ph.D.

Salivary glands > Basal cell adenoma

Eosinophilic hyaline material is present in the tumor nest.

Contributed by Shuanzeng Wei, M.D., Ph.D.

Breast > Cytology

Ductal carcinoma in situ. Clusters of cytologic malignant cells with open chromatin (FNA, Pap stain, 20x).

Contributed by Areej M. Al Nemer, M.D.

16 February 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Bone marrow neoplastic > AML with t(8;21)(q22;q22)

Scattered blasts with prominent eosinophilic granules and rare Auer rods (leftmost blast).

Contributed by Sean Gu, M.D., Ph.D. and Alexa J. Siddon, M.D.

Kidney tumor > Adult renal cell carcinoma – common > Chromophobe eosinophilic variant

Chromophobe renal cell carcinoma eosinophilic variant, demonstrating diffuse marked perinuclear clearing / halos.

Contributed by Timothy Isaac Miller, M.D., M.A. and Maria Tretiakova, M.D., Ph.D.

Liver & intrahepatic bile ducts > Glycogenic hepatopathy

Pale and enlarged hepatocytes in a mosaic pattern with prominent cytoplasmic membranes and scattered background macrovesicular steatosis (200x).

Contributed by Raul S. Gonzalez, M.D.

Ovary > Endometrioid carcinoma

Back to back endometrioid glands; no solid component is seen.

Contributed by Ozlen Saglam, M.D.

Prostate gland & seminal vesicles > Low grade PIN

Atypical acinar cells with few scattered nucleoli growing in a tufted architecture (40x).

Contributed by Nicholas P. Reder, M.D., M.P.H.


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