9 June 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Salivary glands > Mucoepidermoid carcinoma

Solid areas of the tumor are formed by different proportions of epidermoid (squamous) cells (red arrow), mucus cells (green arrow) and intermediate cells (yellow arrow) (histopathology, H&E stain, 10x).

Contributed by Rema A. Rao, M.D. and Saeed Asiry, M.D.

Skin melanocytic tumor > Invasive melanoma

44 year old woman with 0.8 cm nodule on her back. Scanning magnification shows a nodular melanocytic proliferation with minimal junctional component (2x).

Contributed by Michele Donati, M.D.

Skin nonmelanocytic tumor > Keratoacanthoma

An endophytic squamous proliferation with central crater filled with keratin.

Contributed by Poonam Sharma, M.B.B.S.

Bladder, ureter & renal pelvis > Urothelial carcinoma – invasive > Nested

Anastomosing, irregular, large nested and inverted growth of cytologically bland urothelium with desmoplastic stromal reaction (4x).

Contributed by Megan L. Brown, M.D. and Maria Tretiakova, M.D., Ph.D.

Esophagus > Ectopic sebaceous glands

Mature sebaceous gland within the lamina propria.

Contributed by Yukihiro Nakanishi M.D., Ph.D.

26 May 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Salivary glands > Intraductal carcinoma

Cuboidal cells with eosinophilic cytoplasm and small, oval nuclei and inconspicuous nucleoli (H&E, 40x).

Contributed by Kim A. Ely, M.D.

Soft tissue > Perineurioma

Soft tissue perineurioma showing hemangiopericytoma-like growth pattern (H&E, 12.5x).

Contributed by Andrea Saggini, M.D.

Stains & molecular markers > Microphthalmia associated transcription factor (MITF)

MITF highlights the nuclei of the pigmented spindle cells forming nests and fascicles.

Contributed by Ata Moshiri, M.D., M.P.H.

Stains & molecular markers > MCPyV (CM2B4)

The nuclear pattern of CM2B4 immunoreactivity in MCC tumor cells indicates MCPyV positivity. There is an absence of staining in the background nontumoral cells, including inflammatory, endothelial and stromal cells.

Contributed by Thai Yen Ly, M.D.

Ovary > Brenner tumor

This benign Brenner tumor features bland nuclei with conspicuous nuclear grooves in some tumor cells.

Contributed by Jutta Huvila, M.D. and C. Blake Gilks, M.D.

Lymphoma & related disorders > Lymphomatoid granulomatosis

Case 1: lung; H&E staining, Fig 2A: polymorphous infiltrate in scanner view (40x). Fig 2B: lymphocytic vasculitis with infiltration of the vessel wall is seen (100x). Fig 2C: lymphocytic vasculitis with infiltration of the vessel wall is seen (200x). Fig 2D: angioinvasion by lymphoid cells in lymphomatoid granulomatosis (400x).

Contributed by Nicholas Joseph Dcunha, M.B.B.S., M.D. and Elanthenral Sigamani, M.B.B.S., M.D.

19 May 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Lymphoma & related disorders > Large B cell lymphomas-special subtypes > EBV+

Low power view showing large transformed cells admixed with small lymphocytes.

Contributed by Sudhir Perincheri, M.B.B.S., Ph.D.

Lymphoma & related disorders > PTLD-polymorphic

400x magnification image demonstrating a polymorphic lymphoid infiltrate with full maturation, ranging from small, mature lymphoid cells to intermediate to large sized immunoblastic cells. Scattered plasma cells and eosinophils are also seen.

Contributed by Daniel Cassidy, M.D. and Jennifer Chapman, M.D.

Prostate gland & seminal vesicles > Adenosis / atypical adenomatous hyperplasia

Prostate, transurethral resection, adenosis. Medium power view of crowded, closely spaced acini lined by cells with clear cytoplasm and normal size nuclei (H&E, 20x).

Contributed by Cristina Magi-Galluzzi, M.D., Ph.D.

Salivary glands > Basal cell adenoma

Eosinophilic hyaline material is present in the tumor nest.

Contributed by Shuanzeng Wei, M.D., Ph.D.

Breast > Cytology

Ductal carcinoma in situ. Clusters of cytologic malignant cells with open chromatin (FNA, Pap stain, 20x).

Contributed by Areej M. Al Nemer, M.D.

12 May 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Breast > Invasive papillary carcinoma

Right breast, lumpectomy specimen showing invasive papillary carcinoma with desmoplastic reaction at the invasive tumor front without fibrous capsule (H&E, 10x magnification).

Contributed by Marilin Rosa, M.D.

Lymphoma & related disorders > Burkitt lymphoma

Burkitt lymphoma is the fastest growing human tumor. Ki67 positivity is approaching 100% (100x).

Contributed by Saja Asakrah, M.D.

Lymphoma & related disorders > Sézary syndrome

The touch imprint of a lymph node biopsy shows infiltration by small and atypical lymphocytes with cerebriform nuclei and scant cytoplasm.

Contributed by Roberto N. Miranda, M.D.

Lymphoma & related disorders > Associated with primary immune disorders

Reactive lymphoid aggregate in GI biopsy of an IgA deficiency patient, H&E 100x.

Contributed by Jinjun Cheng, M.D., Ph.D.

Salivary glands > Secretory carcinoma

Secretory carcinoma with follicular architecture showing abundant pale eosinophilic colloid-like secretions.

Contributed by Ruta Gupta, M.B.B.S., M.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 59 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

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16 December 2020: Micro Images of the Week

Here is a selection of new images from our free, online textbook:

Adenosis

Expanded terminal duct lobular unit and adjacent (upper left) normal size terminal duct lobular unit (H&E, 4X).

Contributed by Julie M. Jorns, M.D.

Congenital mesoblastic nephroma

Tumor composed of intersecting fascicles of spindle cells.

Contributed by Ellen D’Hooghe, M.D. and Gordan M. Vujanic, M.D., Ph.D.

Large B cell lymphomas: ALK+ LBCL

ALK positive large B cell lymphoma with ALK positivity (bone marrow, IHC, 200x).

Contributed by Marie Therese Manipadam, M.B.B.S., M.D.

Molecular aspects of pancreatic cancer

Site: pancreatic head. Procedure: Whipple resection. Diagnosis: medullary pancreatic ductal adenocarcinoma. Histologic finding: neoplastic cells with syncytial growth and without gland formation (hematoxylin eosin, original magnification 10x). Molecular findings: microsatellite instability is very common in the case of medullary histology.

Contributed by Claudio Luchini, M.D., Ph.D.

Chronic sialadenitis / sialolithiasis

40 year old man with submandibular pain; chronic inflammation with acinar atrophy and fibrosis (10x).

Contributed by James S. Lewis, M.D.

How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 61 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.


25 August 2020: Image Quiz #37

Author: Bin Xu, M.D., Ph.D.

Which histological diagnosis is most likely to correspond to this cytologic aspirate?

Select an answer:

A. Acinic cell carcinoma

B. Adenoid cystic carcinoma

C. Mucoepidermoid carcinoma

D. Secretory carcinoma

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