Authors: Simon F. Roy, M.D., Jennifer M. McNiff, M.D.
What is the histopathological epidermal reaction pattern seen in the image below?
Select an answer:
A. Acantholysis
B. Dyskeratotic acantholysis
C. Epidermal necrosis
D. Epidermolytic hyperkeratosis
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Here is a selection of new images from our free, online textbook:
An organized workspace with a space for all needed tools or materials for jobs done at the station readily allows one to identify when something is missing or out of place.
Contributed by Stephen J. Hardy, M.B.A.
The ductular profiles with complete and incomplete lumina at the portal – parenchymal interface are highlighted by CK19.
Contributed by Shahbaz Khan, M.D.
Right leg, excision, juvenile xanthogranuloma, scattered Touton giant cells.
Contributed by Lamiaa Hamie, M.D., M.Sc. and Ossama Abbas, M.D.
High power showing architectural disorder, loss of polarity and nuclear pleomorphism in high grade papillary carcinoma.
Contributed by Michelle R. Downes, M.D.
Interphase FISH showing translocation involving the EWSR1 gene at 22q12.
Contributed by Ruhani Sardana, M.B.B.S. and Anil Parwani, M.D., Ph.D., M.B.A.
Here is a selection of new images from our free, online textbook:
Solid areas of the tumor are formed by different proportions of epidermoid (squamous) cells (red arrow), mucus cells (green arrow) and intermediate cells (yellow arrow) (histopathology, H&E stain, 10x).
Contributed by Rema A. Rao, M.D. and Saeed Asiry, M.D.
44 year old woman with 0.8 cm nodule on her back. Scanning magnification shows a nodular melanocytic proliferation with minimal junctional component (2x).
Contributed by Michele Donati, M.D.
An endophytic squamous proliferation with central crater filled with keratin.
Contributed by Poonam Sharma, M.B.B.S.
Anastomosing, irregular, large nested and inverted growth of cytologically bland urothelium with desmoplastic stromal reaction (4x).
Contributed by Megan L. Brown, M.D. and Maria Tretiakova, M.D., Ph.D.
Mature sebaceous gland within the lamina propria.
Contributed by Yukihiro Nakanishi M.D., Ph.D.
Here is a selection of new images from our free, online textbook:
Noninvasive lepidic adenocarcinoma (left) juxtaposed with adjacent uninvolved lung parenchyma (right). The lepidic adenocarcinoma is characterized by thickened alveolar septa lined by atypical overlapping cuboidal cells.
Contributed by Jonathan Keow, M.D., Ph.D.
High power view of epithelial lining with maturation of squamous epithelium, which lacks a granular layer (trichilemmal differentiation).
Contributed by Aaron Muhlbauer, M.D. and Jodi Speiser, M.D.
Palisaded granuloma annulare. Arm of a 50 year old woman.
Contributed by Stephen Somach, M.D.
Leiomyosarcoma of the vulva, morphologically low grade, with moderately atypical, round to cigar shaped nuclei with focally prominent nucleoli (400x). Mitoses are rare (1 – 2 per 10 high power fields) and necrosis is absent.
Contributed by David B. Chapel, M.D.
A low power view shows papillary / verrucous epithelial hyperplasia with band-like plasma cell infiltrate in the scrotum.
Contributed by Liwei Jia, M.D., Ph.D.
Anterior cranial base fractures (yellow arrows).
Contributed by Lorenzo Gitto, M.D., Robert Stoppacher, M.D., Serenella Serinelli M.D., Ponni Arunkumar, M.D. and Luigi Bonaccorso, M.D.
Here is a selection of new images from our free, online textbook:
Cytomorphologically, lesional cells are highly bizarre and atypical, with marked pleomorphism in size and shape, abundant eosinophilic cytoplasm, occasional multinucleation and numerous mitotic figures, including atypical forms (H&E, 200x).
Contributed by Pavandeep Gill, M.D. and Phyu Aung, M.D., Ph.D.
Higher magnification shows Enterobius eggs with 1 flattened side and 1 convex side and a double layer hyaline chitin shell.
Contributed by Eiman Adel Hasby, M.D.
Bone marrow biopsy from a patient with aCML showing markedly hypercellular bone marrow with markedly increased neutrophils and myeloid precursors and mild dysmegakarypoiesis with no increase in blasts.
Contributed by Ling Zhang, M.D.
Undifferentiated carcinoma at high power. Sheets of clearly high grade cells without obvious pattern of differentiation into any given cell type.
Contributed by Rondell P. Graham, M.B.B.S.
For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 59 chapters are listed, as demonstrated below.
For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.
For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.
Here is a selection of new images from our free, online textbook:
At high magnification, HSIL / CIN III lacks maturation (400x).
Contributed by Khaled J. Alkhateeb, M.B.B.S.
Ovarian fibroma: the cut surface reveals a dense white mass within the ovary (left); outer surface of the fibroma is smooth and lightly vascularized (right).
Contributed by Rex Bentley, M.D.
Low power view of numerous small uniform spaces (microfollicles) with hyalinized basement membrane material (Call-Exner bodies).
Contributed by Kristine M. Cornejo, M.D.
Evaluation of fungal forms. H&E stained FFPE tissue showing broad pauciseptate ribbon-like hyphae in necrotic sinonasal tissue.
Contributed by Sixto M. Leal, Jr., M.D., Ph.D.
Histologic sections showing cysts, nests and cords in a paisley or tadpole shaped pattern. No cytologic atypia or mitotic figures are seen (H&E, original magnification 100x).
Contributed by Aadil Ahmed, M.D. and Sara C. Shalin, M.D., Ph.D.
For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.
For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.
For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.
Here are just a few of this week’s new images from our free, online textbook:
Degenerated infected cell with vesicular nucleus showing spider web chromatin (bladder washing, ThinPrep, 60x).
Written by Gong Feng, M.D., Ph.D., Bonnie Choy, M.D.
H&E image showing the epithelial component (bottom) and the stromal component (top).
Written by Rose Chami, M.D.
Cheek biopsy: trichoepithelioma with prominent keratin cyst formation. Note the bland cytologic features, cellular stroma and lack of epithelial stromal clefting (H&E, 100x magnification).
Written by Eleanor Russell-Goldman, M.D., Ph.D.
Strong, diffuse nuclear expression of PAX8 in metastatic renal cell carcinoma involving the lung on needle core biopsy.
Written by Kelsey E. McHugh, M.D.
Papillary thyroid carcinoma, thyroid FNA: intranuclear cytoplasmic inclusion (arrow) and powdery chromatin (Papanicolaou, 40x).
Written by Ayana Suzuki, C.T., Andrey Bychkov, M.D., Ph.D.
For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 61 chapters are listed, as demonstrated below.
For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.
For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.
Authors: V. Claire Vaughan, M.D., Joshua Wisell, M.D.
An elderly man presents to the dermatology clinic with a flesh colored papule over the lateral cheek without arborizing vessels or crust. Biopsy is shown. What is the most likely diagnosis?
Select an answer:
A. Basal cell carcinoma
B. Basaloid follicular hamartoma
C. Syringoma
D. Trichoblastoma
E. Spiradenoma
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