15 February 2022: Image Quiz #76

Authors: Josephine K. Dermawan, M.D., Ph.D.Karen Fritchie, M.D.

A 54 year old woman presents with a 9.6 cm, well circumscribed, firm mass in the deep soft tissue of the thigh. Histologic sections show ovoid to spindled cells arranged haphazardly around prominent, thin walled, hyalinized, dilated, staghorn type vasculature (see image below). Which of the following is the most sensitive and specific immunohistochemical marker for the diagnosis of this tumor?

Select an answer:

A. Actin

B. BCL2

C. CD34

D. Cytokeratin CAM 5.2

E. STAT6

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20 April 2021: Image Quiz #54

Author: Borislav A. Alexiev, M.D.

Which of the following is true about composite hemangioendothelioma?

Select an answer:

A. Harbors WWTR1-CAMTA1 fusions

B. Harbors ZFP36-FOSB fusions

C. HHV8+

D. Typically does not recur after excision

E. Distinguishing from other vascular neoplasms largely lies in finding different histologic vascular patterns within 1 lesion

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