14 April 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Skin nonmelanocytic tumor > Atypical fibroxanthoma

Cytomorphologically, lesional cells are highly bizarre and atypical, with marked pleomorphism in size and shape, abundant eosinophilic cytoplasm, occasional multinucleation and numerous mitotic figures, including atypical forms (H&E, 200x).

Contributed by Pavandeep Gill, M.D. and Phyu Aung, M.D., Ph.D.

Stomach > Fundic gland polyp

Cystically dilated glands.

Contributed by Naziheh Assarzadegan, M.D.

Appendix > Enterobius vermicularis

Higher magnification shows Enterobius eggs with 1 flattened side and 1 convex side and a double layer hyaline chitin shell.

Contributed by Eiman Adel Hasby, M.D.

Bone marrow neoplastic > Atypical chronic myeloid leukemia

Bone marrow biopsy from a patient with aCML showing markedly hypercellular bone marrow with markedly increased neutrophils and myeloid precursors and mild dysmegakarypoiesis with no increase in blasts.

Contributed by Ling Zhang, M.D.

Esophagus > Undifferentiated carcinoma

Undifferentiated carcinoma at high power. Sheets of clearly high grade cells without obvious pattern of differentiation into any given cell type.

Contributed by Rondell P. Graham, M.B.B.S.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 59 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

24 March 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Breast > Filariasis

Classic “double barrel” uterus of the adult female worm (Wuchereria bancrofti) with eggs and developing larvae (microfilariae) in a lymph node (H&E, 10x).

Contributed by Bobbi Pritt, M.D.

Stains & molecular markers > Carbonic anhydrase IX

Diffuse circumferential membranous staining in clear cell RCC.

Contributed by Nick Baniak, M.D.

Stomach > MALT lymphoma

Infiltration and distortion of epithelial structures by aggregates of (usually 3 or more) neoplastic lymphoid cells.

Contributed by Kwun Wah Wen, M.D., Ph.D.

Testis & epididymis > Sex cord-stromal tumors > Leydig cell

Leydig cell tumor with sheets of polygonal cells with eosinophilic cytoplasm (H&E stain; 10x magnification).

Contributed by Manju Aron, M.D.

Autopsy & forensics > Therapy related deaths

Autopsy image of a percutaneous biliary catheter in the portal vein. The biliary drain placement was performed to relieve a biliary stricture but the catheter was placed in the portal vein adjacent to the targeted bile duct resulting in hemoperitoneum. The end of the catheter was cut during removal of the liver as this was an unexpected finding at autopsy.

Contributed by Mark A. Giffen, Jr., D.O.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

17 March 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Skin nontumor > Warts (verrucae)

Hyperkeratosis, papillomatosis, hypergranulosis, koilocytosis and inward bending of rete ridges at borders of lesion. Dermal papillae show dilated capillaries.

Contributed by Heba Ahmed Abdelkader, M.D.

Small intestine & ampulla > Lymphangioma

Scanning magnification shows the dilated lymphatics in the submucosa of the small intestine (H&E, 2x).

Contributed by Haider A. Mejbel, M.D.

Stomach > Pyloric gland adenoma

High power view of PGA showing small tubular glands with low cuboidal epithelium and bland nuclei.

Contributed by Supriya Srivastava M.D., Ph.D.

Bone & joints > Adamantinoma

Anastomosing thin trabeculae of mildly atypical epithelioid and spindled cells within fibrous stroma.

Contributed by Borislav A. Alexiev, M.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

3 February 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Soft tissue > Sclerosing epithelioid fibrosarcoma

Sclerosing epithelioid fibrosarcoma with EWSR1-CREB3L1 fusion. Small, round to ovoid epithelioid cells with sparse, often clear cytoplasm and round to oval nuclei.

Contributed by Borislav A. Alexiev, M.D.

Stains > HPV (Human papillomavirus)

p16 diffuse and strong nuclear and cytoplasmic staining in HSIL.

Contributed by Ana Félix, M.D., Ph.D.

Stomach > Carcinoma-general

Gastric tumor with linitis plastica pattern: diffuse rugal flattening and thickening of the gastric wall. Note the absence of a well defined tumor mass.

Contributed by Clara Alfaro, M.D., Ph.D.

Vulva, vagina & female urethra > Condyloma

Condyloma acuminatum of the vulva with acanthosis, papillomatosis and basal fusion of broad papillae. There are no significant viral specific changes of the epithelium.

Contributed by Matthias Choschzick, M.D.


How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.