16 June 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Laboratory Administration & Management of Pathology Practices > Lean workflow / Six Sigma

An organized workspace with a space for all needed tools or materials for jobs done at the station readily allows one to identify when something is missing or out of place.

Contributed by Stephen J. Hardy, M.B.A.

Liver & intrahepatic bile ducts > Ductular reaction

The ductular profiles with complete and incomplete lumina at the portal – parenchymal interface are highlighted by CK19.

Contributed by Shahbaz Khan, M.D.

Skin nonmelanocytic tumor > Juvenile xanthogranuloma

Right leg, excision, juvenile xanthogranuloma, scattered Touton giant cells.

Contributed by Lamiaa Hamie, M.D., M.Sc. and Ossama Abbas, M.D.

Bladder, ureter & renal pelvis > Noninvasive papillary urothelial carcinoma high grade

High power showing architectural disorder, loss of polarity and nuclear pleomorphism in high grade papillary carcinoma.

Contributed by Michelle R. Downes, M.D.

Informatics, digital & computational pathology > Fluorescent microscopy applications

Interphase FISH showing translocation involving the EWSR1 gene at 22q12.

Contributed by Ruhani Sardana, M.B.B.S. and Anil Parwani, M.D., Ph.D., M.B.A.

9 June 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Salivary glands > Mucoepidermoid carcinoma

Solid areas of the tumor are formed by different proportions of epidermoid (squamous) cells (red arrow), mucus cells (green arrow) and intermediate cells (yellow arrow) (histopathology, H&E stain, 10x).

Contributed by Rema A. Rao, M.D. and Saeed Asiry, M.D.

Skin melanocytic tumor > Invasive melanoma

44 year old woman with 0.8 cm nodule on her back. Scanning magnification shows a nodular melanocytic proliferation with minimal junctional component (2x).

Contributed by Michele Donati, M.D.

Skin nonmelanocytic tumor > Keratoacanthoma

An endophytic squamous proliferation with central crater filled with keratin.

Contributed by Poonam Sharma, M.B.B.S.

Bladder, ureter & renal pelvis > Urothelial carcinoma – invasive > Nested

Anastomosing, irregular, large nested and inverted growth of cytologically bland urothelium with desmoplastic stromal reaction (4x).

Contributed by Megan L. Brown, M.D. and Maria Tretiakova, M.D., Ph.D.

Esophagus > Ectopic sebaceous glands

Mature sebaceous gland within the lamina propria.

Contributed by Yukihiro Nakanishi M.D., Ph.D.