25 April 2023: Case of the Month #526

Thanks to Dr. Stephanie Skala, University of Michigan, Ann Arbor, Michigan, USA for contributing this case and discussion and to Dr. Gulisa Turashvili, Emory University School of Medicine, Atlanta, Georgia for reviewing the discussion.

Clinical history:

A 62 year old woman presented with post-menopausal bleeding. A subsequent biopsy was diagnosed as high grade endometrial carcinoma. She underwent a hysterectomy.

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All cases are archived on our website. To view them sorted by case number, diagnosis or category, visit our main Case of the Month page.

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Note: This case was originally emailed to our e-newsletter subscribers on April 20, 2023.

2 February 2022: Best Authors of 2021

Congratulations to the winners of the PathologyOutlines.com 2021 Best Author Award! This was a very competitive award and we greatly appreciate the contributions of those named below in addition to those of our other diligent authors in 2021, all of whom you can view here. You can view the winners from past years here.

Here are the 2021 winners:

1. Oral cavity & oropharynx > Oropharynx squamous cell carcinoma > HPV negative: Written by Katherine Hulme, M.B.Ch.B. and Ruta Gupta, M.D. 
2. Uterus > Stromal tumors > Low grade endometrial stromal sarcoma: Written by Elizabeth Kertowidjojo, M.D., Ph.D., M.P.H. and Lora Hedrick Ellenson, M.D. 
3. Breast > Papillary carcinoma > Solid papillary carcinoma: Written by Sofia Lérias, M.D. and Melinda Lerwill, M.D. 
4. CNS tumor > Other tumors > Hemangioblastoma: Written by Rebecca Yoda, M.D. and P.J. Cimino, M.D., Ph.D. 
5. Liver > Other malignancies > Hepatoblastoma: Written by Rui Caetano Oliveira, M.D. and Maria Augusta Cipriano, M.D. 

If you are interested in being an author for PathologyOutlines.com, please send your CV and a list of topics or chapters you are interested in writing / reviewing to our author coordinators at Authors@PathologyOutlines.com. You may also review your qualifications here.

23 June 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Informatics, digital & computational pathology > Data representation and communication standards

The PNG image has been encoded into JPG using a high quality setting (approximately 329 KB).

Contributed by Chris Williams, M.D.

Uterus > Low grade endometrial stromal sarcoma

Deceptively well circumscribed tumor with a tan-yellow soft cut surface; microscopic evaluation revealed myometrial and lymphovascular invasion.

Contributed by Elizabeth Kertowidjojo, M.D., Ph.D., M.P.H.

Colon > Ulcerative colitis

Active chronic colitis with cryptitis is noted.

Contributed by Rachel Horton, D.O. and Catherine E. Hagen, M.D.

Liver & intrahepatic bile ducts > Histology

Periodic acid-Schiff with diastase (PASD) highlights the basement membrane of bile ducts. It also stains alpha-1 antitrypsin globules in hepatocytes in the setting of alpha-1 antitrypsin deficiency. The lack of globules in this image is a normal finding.

Contributed by Kimberley J. Evason, M.D., Ph.D.

Ovary > Yolk sac tumor

Schiller-Duval body

Contributed by Sharon Song, M.D.

5 May 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Bone & joints > Chondrosarcoma (primary, secondary, periosteal)

There is obvious nuclear atypia and pleomorphism but the background is distinctly chondroid.

Contributed by Shadi Qasem, M.D.

Bone marrow neoplastic > Myeloid / lymphoid neoplasms with eosinophilia and gene rearrangement > PCM1-JAK2

Bone marrow clot showing large, abnormal aggregate of early erythroid precursors. Also note dysplastic megakaryocytes (H&E stain, 200x).

Contributed by Zeba N. Singh, M.B.B.S., M.D.

Lymphoma & related disorders > HHV8 related germinotropic lymphoproliferative disorder

Large atypical cells with anaplastic features.

Contributed by Julie Teruya-Feldstein, M.D.

Lymphoma & related disorders > Indolent T lymphoproliferative disease of the GI tract

Majority of T cells in the infiltrate are CD8 positive.

Contributed by Anamarija M. Perry, M.D.

Uterus > Leiomyoma-general > FH deficient leiomyoma

Spindle or epithelioid cells with ovoid nuclei and prominent eosinophilic nucleoli surrounded by perinucleolar halos.

Contributed by Sabrina Croce, M.D., Ph.D.

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31 May 2019: New Mystery Case

We have posted a new Mystery Case on PathologyOutlines.com! Can you guess the diagnosis? Check out our home page for more about our latest mystery case! #pathology #pathologist #uterus #GYN #gynocologic #diagnosis