2 June 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Lung > Lepidic adenocarcinoma

Noninvasive lepidic adenocarcinoma (left) juxtaposed with adjacent uninvolved lung parenchyma (right). The lepidic adenocarcinoma is characterized by thickened alveolar septa lined by atypical overlapping cuboidal cells.

Contributed by Jonathan Keow, M.D., Ph.D.

Skin nonmelanocytic tumor > Trichilemmal (pilar) type cysts

High power view of epithelial lining with maturation of squamous epithelium, which lacks a granular layer (trichilemmal differentiation).

Contributed by Aaron Muhlbauer, M.D. and Jodi Speiser, M.D.

Skin nontumor > Granuloma annulare

Palisaded granuloma annulare. Arm of a 50 year old woman.

Contributed by Stephen Somach, M.D.

Vulva, vagina & female urethra > Smooth muscle tumors

Leiomyosarcoma of the vulva, morphologically low grade, with moderately atypical, round to cigar shaped nuclei with focally prominent nucleoli (400x). Mitoses are rare (1 – 2 per 10 high power fields) and necrosis is absent.

Contributed by David B. Chapel, M.D.

Penis & scrotum > Cutaneous verruciform xanthoma

A low power view shows papillary / verrucous epithelial hyperplasia with band-like plasma cell infiltrate in the scrotum.

Contributed by Liwei Jia, M.D., Ph.D.

Autopsy & forensics > Blunt force injuries

Anterior cranial base fractures (yellow arrows).

Contributed by Lorenzo Gitto, M.D., Robert Stoppacher, M.D., Serenella Serinelli M.D., Ponni Arunkumar, M.D. and Luigi Bonaccorso, M.D.

16 November 2020: Images of the Week

Here are just a few of this week’s new images from our free, online textbook:


Hepatic angiomyolipoma showing characteristic mixture of smooth muscle cells, adipocytes and blood vessels (upper right).

Written by Kimberley J. Evason, M.D., Ph.D.

Myoepithelioma / myoepithelial carcinoma / mixed tumor

Myoepithelioma of soft tissue. Proliferation of epithelioid cells with clear cytoplasm.

Written by Borislav A. Alexiev, M.D.William B. Laskin, M.D.

Carcinosarcoma (MMMT)

A high power figure of a biphasic neoplasm composed of highly malignant epithelioid and spindle cells and prominent chondroid-like matrix.

Written by Joana Ferreira, M.D.Ana Félix, M.D., Ph.D.

Cellular angiofibroma

Short fascicles of bland spindle cells admixed with small hyalinized vessels (100x).

Written by David B. Chapel, M.D.Jennifer Bennett, M.D.

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