2 June 2021: Pathology Images of the Week

Here is a selection of new images from our free, online textbook:

Lung > Lepidic adenocarcinoma

Noninvasive lepidic adenocarcinoma (left) juxtaposed with adjacent uninvolved lung parenchyma (right). The lepidic adenocarcinoma is characterized by thickened alveolar septa lined by atypical overlapping cuboidal cells.

Contributed by Jonathan Keow, M.D., Ph.D.

Skin nonmelanocytic tumor > Trichilemmal (pilar) type cysts

High power view of epithelial lining with maturation of squamous epithelium, which lacks a granular layer (trichilemmal differentiation).

Contributed by Aaron Muhlbauer, M.D. and Jodi Speiser, M.D.

Skin nontumor > Granuloma annulare

Palisaded granuloma annulare. Arm of a 50 year old woman.

Contributed by Stephen Somach, M.D.

Vulva, vagina & female urethra > Smooth muscle tumors

Leiomyosarcoma of the vulva, morphologically low grade, with moderately atypical, round to cigar shaped nuclei with focally prominent nucleoli (400x). Mitoses are rare (1 – 2 per 10 high power fields) and necrosis is absent.

Contributed by David B. Chapel, M.D.

Penis & scrotum > Cutaneous verruciform xanthoma

A low power view shows papillary / verrucous epithelial hyperplasia with band-like plasma cell infiltrate in the scrotum.

Contributed by Liwei Jia, M.D., Ph.D.

Autopsy & forensics > Blunt force injuries

Anterior cranial base fractures (yellow arrows).

Contributed by Lorenzo Gitto, M.D., Robert Stoppacher, M.D., Serenella Serinelli M.D., Ponni Arunkumar, M.D. and Luigi Bonaccorso, M.D.

3 February 2021: Images of the Week

Here is a selection of new images from our free, online textbook:

Soft tissue > Sclerosing epithelioid fibrosarcoma

Sclerosing epithelioid fibrosarcoma with EWSR1-CREB3L1 fusion. Small, round to ovoid epithelioid cells with sparse, often clear cytoplasm and round to oval nuclei.

Contributed by Borislav A. Alexiev, M.D.

Stains > HPV (Human papillomavirus)

p16 diffuse and strong nuclear and cytoplasmic staining in HSIL.

Contributed by Ana Félix, M.D., Ph.D.

Stomach > Carcinoma-general

Gastric tumor with linitis plastica pattern: diffuse rugal flattening and thickening of the gastric wall. Note the absence of a well defined tumor mass.

Contributed by Clara Alfaro, M.D., Ph.D.

Vulva, vagina & female urethra > Condyloma

Condyloma acuminatum of the vulva with acanthosis, papillomatosis and basal fusion of broad papillae. There are no significant viral specific changes of the epithelium.

Contributed by Matthias Choschzick, M.D.

---

How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.

16 November 2020: Images of the Week

Here are just a few of this week’s new images from our free, online textbook:

Angiomyolipoma

Hepatic angiomyolipoma showing characteristic mixture of smooth muscle cells, adipocytes and blood vessels (upper right).

Written by Kimberley J. Evason, M.D., Ph.D.

Myoepithelioma / myoepithelial carcinoma / mixed tumor

Myoepithelioma of soft tissue. Proliferation of epithelioid cells with clear cytoplasm.

Written by Borislav A. Alexiev, M.D., William B. Laskin, M.D.

Carcinosarcoma (MMMT)

A high power figure of a biphasic neoplasm composed of highly malignant epithelioid and spindle cells and prominent chondroid-like matrix.

Written by Joana Ferreira, M.D., Ana Félix, M.D., Ph.D.

Cellular angiofibroma

Short fascicles of bland spindle cells admixed with small hyalinized vessels (100x).

Written by David B. Chapel, M.D., Jennifer Bennett, M.D.

How can you search the textbook?

For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 61 chapters are listed, as demonstrated below.

For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.

For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.