Here are just a few of this week’s new images from our free, online textbook:
Autoimmune enteropathy
400x magnification image of a duodenal biopsy from a 6 year old boy highlighting severe villous blunting, absence of goblet cells and Paneth cells.
Written by Archana Shenoy, M.D., Pierre A. Russo, M.D
Chromophobe carcinoma
ChRCC with characteristic plant-like membranes and frequent binucleation, 400x.
Written by Maria Tretiakova, M.D., Ph.D.
Collagenous spherulosis
Collagenous spherulosis showing expanded duct with cribriform spaces lined by myoepithelial cells and filled with eosinophilic basement membrane material.
Written by Iskender Sinan Genco, M.D., Sabina Hajiyeva, M.D.
High grade endometrial stromal sarcoma
High grade endometrial stromal sarcoma with high grade component consisting of round cells and spindle cells with mild to severe nuclear pleiomorphism.
Written by Ondrej Ondič, M.D., Ph.D.
Image analysis
(Top row) Digital image analysis detected and quantified PDL1 in all cells of whole tissue sections and in separate tumor / stroma interface compartments. Tumor cells were scored using a binning approach, which scores PDL1 intensities of 0, 1, 2 and 3+ (highlighted in markup respectively as blue, yellow, orange and red). (Bottom row) Lymphocytes detected using morphological features were scored for negative or positive PDL1 status (highlighted in markup as blue or red cells, respectively) and stratified in each tissue compartment. Detected lymphocytes in the tumor compartment were subtracted from the PDL1 scoring of tumor compartments to provide accurate assessment of tumor cells within the tumor nest.
Written by by Charles Caldwell, Ph.D., Vitria Adisetiyo, Ph.D., Cris Luengo, Ph.D., Roberto Gianani, M.D.
How can you search the textbook?
For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 61 chapters are listed, as demonstrated below.
For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.
For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.
Blog | PathologyOutlines.com 