17 February 2021: Case of the Month #500

Thanks to Dr. Sakinah A. Thiryayi and Dr. Gulisa Turashvili, Mount Sinai Hospital, Toronto (Canada) for contributing this case and writing the discussion and to Dr. Ricardo R. Lastra, University of Chicago Medical Center, Chicago, Illinois (USA), for reviewing the discussion.

Clinical history:

A 52 year old woman was found to have an ovarian mass on computed tomography imaging and an elevated CA-125 of 234 U/mL (reference range: less than 46 U/mL). The mass was excised.

All cases are archived on our website. To view them sorted by case number, diagnosis or category, visit our main Case of the Month page.

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15 January 2021: Weekly Roundup #32


This is what’s new on PathologyOutlines.com:

1. Dr. Pernick’s Curing Cancer Blog

Dr. Pernick has written his fourth essay about curing cancer based on complexity theory. Click here for a PDF download or read the essay here. You can also follow his blog for regular updates directly to your inbox. In part 3, he summarized recommendations on curative treatment for advanced adult cancers with a poor prognosis, such as lung and pancreatic cancer. In this essay, he discusses these principles of curative treatment in greater depth: network medicine, blocking multiple pathways, combinations of combinations of treatment, monitoring key networks, clinical trials and strong public health programs. He is happy to respond to comments or questions at Nat@PathologyOutlines.com.

See also Curing cancer, Part 1 – Reductionism vs. Complexity, Curing Cancer, Part 2 – Adult vs. Childhood Cancer and Curing Cancer – Part 3 – Curative cancer treatment based on complexity theory.

2. What’s New This Week Video

We have a new short video, This Week At PathologyOutlines.com, posted on our homepage and on our YouTube channel. We also have a text summary in the description box of the YouTube video if you are in a hurry.

3. New COVID-19 Article

Our COVID-19 library (click on “Libraries” in our site navigation, then select COVID-19 Library) has a new article, FDA Issues Alert Regarding SARS-CoV-2 Viral Mutation, posted 8 January 2021.

4. Case #499

Case #499 was posted on January 14. You can also sign up for our monthly case newsletters and more here.

5. Author Payment

As of September 2020, we stopped paying authors with 3+ topics, although we will honor payment to authors who wrote 3+ topics before the end of 2020. Please give us time to contact you about payment or feel free to contact us by 31 January 2021 at Authors@PathologyOutlines.com if you believe you are owed money for author topics.

6. Website Traffic in 2020

Despite the COVID-19 pandemic, our website traffic was still up 3.5% in 2020 compared to 2019. Average traffic in 2020 was 40,628 visits / day, with over 32 million pageviews sitewide. As always thank you for your support and please contact us at CommentsPathOut@gmail.com with any suggestions on how to improve the website.

11 December 2020: Weekly Roundup #29


This is what’s new on PathologyOutlines.com this week:

1. View Prior Jobs, Fellowships, Conferences Pages

We’ve posted versions of the Jobs, Fellowships, and Conferences pages as of December 1, 2020. If you need to look up a previous ad, we maintain these files as of the first of each month (or close to it). See files below:

As of December 1, 2020: JobsFellowshipsConferences 

The format is the name of the file, plus yyyymm, where yyyy is the year and mm is the month.  For example, jobs posted as of December 1, 2020 are at http://www.pathologyoutlines.com/jobs202012.html.

Please contact us with any questions at CommentsPathOut@gmail.com.

2. Topic Dates

All topics list 2 dates: topic completion date and minor changes.

Topic Completed is when the topic was last reviewed / revised / rewritten, from top to bottom. This helps us decide when a topic needs to be rewritten. 

Minor changes indicates when any change was made, however small. It might be punctuation or a typo. It is useful to PathologyOutlines.com staff to tell us that something that needed to be completed was actually done.

See an example of topic dates below.

3. Case #498

Case #498 was posted on December 10. To view it, click here. You can also sign up for our monthly case newsletters and more on this page.

27 November 2020: Weekly Roundup #27


This is what’s new on PathologyOutlines.com this week:

1. What’s New This Week

We have a new video, What’s New at PathologyOutlines.com in 90 seconds, posted on our homepage and on our YouTube channel. We also have a text summary if you are in a hurry.

2. New COVID-19 Article

Read the new article in our COVID-19 library: COVID-19 Antibodies May Provide Long-term Immunity, posted 24 November 2020; see also Science 2020 Oct 28 [Online ahead of print].

3. COVID-19 Pathology Related Experiences

Share your unique, interesting pathology related experiences concerning COVID-19 with pathologists around the world through PathologyOutlines.com. Email Dr. Pernick with up to 500 words about your experience at Nat@PathologyOutlines.com.

4. Talk to Us

How has PathologyOutlines.com been useful to you? Send us a 30 second video for possible posting on our YouTube page. You may email your video to Nat@PathologyOutlines.com or mention us on Twitter or Instagram.

5. Case of the Month #497

Our 497th case was posted last Thursday, 19th November. To view case #497, click here. You can also sign up for our monthly case newsletters and more on this page.

14 October 2020: Case of the Month #496

Thanks to Dr. Cheng Wang, Dalhousie University and Nova Scotia Health Authority, Halifax, NS (Canada) and the Genitourinary Pathology Society (GUPS) for contributing this case and discussion.

Clinical history:

A woman in her early 50s presented with multiple broad based bladder mucosal lesions seen on cystoscopic examination.

All cases are archived on our website. To view them sorted by case number, diagnosis or category, visit our main Case of the Month page.

To subscribe to Case of the Month or our other email lists, click here.

16 September 2020: Case of the Month #495

Thanks to Dr. Tanner Storozuk and Dr. Jennifer A. Bennett, University of Chicago, Illinois (USA), for contributing this case and writing the discussion.

Clinical history:

A 34 year old woman was found to have atypical glandular cells of undetermined significance on Pap smear. She underwent a cervical biopsy and the results are depicted below. She had a hysterectomy afterwards that showed residual disease. Pap smears for the following 3 years were negative.

All cases are archived on our website. To view them sorted by case number, diagnosis or category, visit our main Case of the Month page.

To subscribe to Case of the Month or our other email lists, click here.

12 August 2020: Case of the Month #494

Thanks to Dr. Farres Obeidin, UCLA Medical Center, California (USA), and Dr. Borislav Alexiev, Northwestern University Feinberg School of Medicine, Illinois (USA), for contributing this case and to Dr. Farres Obeidin for writing the discussion.

Clinical history:

A 49 year old man with no significant medical history presented with symptoms of nasal obstruction. CT imaging revealed a large right nasal mass with involvement of the ethmoid sinus. An excisional biopsy was performed and reveals the morphology below.

All cases are archived on our website. To view them sorted by case number, diagnosis or category, visit our main Case of the Month page.

To subscribe to Case of the Month or our other email lists, click here.

15 July 2020: Case of the Month #493

Thanks to Dr. Kelly Magliocca, Emory University, Atlanta, Georgia (USA), for contributing this case and writing the discussion.

Clinical history:

A 26 year old man presented with refractory AML and sinus pain. The patient underwent debridement of non-viable tissue from the nasal septum and turbinates.

All cases are archived on our website. To view them sorted by case number, diagnosis or category, visit our main Case of the Month page.

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17 June 2020: Case of the Month #492

Thanks to Dr. Raul Gonzalez, Beth Israel Deaconess Medical Center, Boston, Massachusetts (USA), for contributing this case and writing the discussion.

A 68 year old woman with a history of Crohn’s disease presented with small bowel perforation.

All cases are archived on our website. To view them sorted by case number, diagnosis or category, visit our main Case of the Month page.

To sign up for our Case of the Month newsletters and more, visit http://www.pathologyoutlines.com/subscribe.html and type your email into the box.

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13 May 2020: Case of the Month #491

A 39 year old man presented with a painful, slowly enlarging testicular mass. A left radical orchiectomy was performed.

To sign up for our Case of the Month newsletters and more, visit http://www.pathologyoutlines.com/subscribe.html and type your email into the box.