27 March 2024: Case of the Month #537

Thanks to Drs. Sherif Shabaan and Julie Jorns, Medical College of Wisconsin, Milwaukee, Wisconsin, USA for contributing this case and discussion and to Dr. Kristen Muller, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA for reviewing the discussion.

Clinical history:

A 26 year old woman had a grade 2 invasive ductal carcinoma and ipsilateral axillary lymph node metastasis at diagnosis. She received neoadjuvant therapy with anti-PD1, taxane, adriamycin and cyclophosphamide, followed by granulocyte colony stimulating factor. She then had a sentinel lymph node excision, shown here.

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This e-newsletter was originally sent to our subscribers on March 22, 2024.

17 January 2024: Case of the Month #535

Thanks to Dr. Borislav Alexiev, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA for contributing this case and discussion and to Dr. Jefree J. Schulte, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA for reviewing the discussion.

Clinical history:

A 79 year old patient presented with a pulmonary arterial mass. The tumor showed the following findings.

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22 December 2023: Case of the Month #534

Thanks to Dr. Gulisa Turashvili, Emory University School of Medicine, Atlanta, Georgia, USA for contributing this case and discussion.

Clinical history:

A 46 year old woman underwent a total hysterectomy for uterine leiomyomas. A representative section of the grossly unremarkable cervix showed the following findings.

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22 November 2023: Case of the Month #533

Thanks to Drs. Azadeh Khayyat and Julie Jorns, Medical College of Wisconsin, Milwaukee, Wisconsin, USA for contributing this case and discussion and to Dr. Gary Tozbikian, Ohio State University Wexner Medical Center, Columbus, Ohio, USA for reviewing the discussion.

Clinical history:

A premenopausal woman with family history of breast cancer in paternal and maternal grandmothers presented for first screening mammogram and was found to have a subcentimeter mass with calcifications for which she underwent stereotactic guided core biopsy.

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19 October 2023: Case of the Month #532

Thanks to Dr. Chunyu Cai, University of Texas Southwestern Medical Center, Dallas, Texas, USA for contributing this case and discussion and to Dr. Jared Ahrendsen, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA for reviewing the discussion.

Clinical history:

A 52 year old man with a history of HIV infection and Kaposi sarcoma 5 years prior, presented with lower extremity weakness. His CD4 count was low (29). Brain MRI showed multiple enhancing brain lesions, predominantly located at the gray-white interfaces.

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13 September 2023: Case of the Month #531

Thanks to Drs. Aaron Huber and Diana Agostini-Vulaj, University of Rochester Medical Center, Rochester, New York, USA for contributing this case and discussion and to Dr. Raul Gonzalez, Emory University School of Medicine, Atlanta, Georgia, USA for reviewing the discussion.

Clinical history:

An 85 year old woman with a remote history of right sided colon cancer underwent a transverse colon resection for a newly diagnosed colon cancer.

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16 August 2023: Case of the Month #530

Thanks to Drs. Kristen Muller and Samantha Stephen, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA for contributing this case and discussion and to Dr. Julie Jorns, Medical College of Wisconsin, Milwaukee, Wisconsin, USA for reviewing the discussion.

Clinical history:

A 66 year old woman with a history of right sided invasive lobular carcinoma in 2009 (ER+ / PR- / HER2-) and ipsilateral recurrence in 2018 was status post bilateral mastectomy with breast implant reconstruction. She developed rib pain and CT of the chest showed an asymmetric 4.8 cm soft tissue mass overlying the anterior fourth rib. Ultrasound revealed a hypoechoic ill defined mass with high vascularity. A biopsy was performed.

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18 July 2023: Case of the Month #529

Thanks to Dr. Hyunkyu Shin, Dr. Christian Schürch and Dr. Falko Fend, University Hospital and Comprehensive Cancer Center, Tübingen, Germany and Dr. Claudia Wickenhauser, University Hospital Halle (Saale), Germany for contributing this case and discussion and to Dr. Julie Feldstein, Histowiz.com, New York, New York, USA for reviewing the discussion.

Clinical history:

A 52 year old man with a neoadjuvantly treated gastrointestinal stromal tumor (GIST) of the stomach had a gastrectomy. In the histologic examination of the resected tumor, accumulations of discohesive large cells in cystic spaces of the regressively changed tumor bed of the GIST were noticed, as shown in the following image.

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21 June 2023: Case of the Month #528

Thanks to Dr. Bin Xu, Memorial Sloan Kettering Cancer Center, New York, New York, USA for contributing this case and discussion and to Dr. Marc Pusztaszeri, McGill University, Montreal, Quebec, Canada for reviewing the discussion.

Clinical history:

A 19 year old woman presented with a 3.7 cm thyroid mass.

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22 May 2023: Case of the Month #527

Thanks to Dr. Raul Gonzalez, Emory University School of Medicine, Atlanta, Georgia, USA for contributing this case and discussion and to Dr. Naziheh Assarzadegan, University of Florida, Gainesville, Florida, USA for reviewing the discussion.

Clinical history:

A 45 year old man presents to a gastroenterologist complaining of constipation and rectal bleeding. A single ulcerated rectal lesion is found on colonoscopy and is biopsied.

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All cases are archived on our website. To view them sorted by case number, diagnosis or category, visit our main Case of the Month page.

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Note: This case was originally emailed to our e-newsletter subscribers on May 18, 2023.