2 June 2020: Biweekly Image Quiz #32

Author: Jayalakshmi Balakrishna, M.D.

A 20 year old man presents with an enlarged painless cervical lymph node he has had for 6 months. An excisional biopsy is shown in the image. The neoplastic cells are positive for CD45 and CD20 and are negative for CD15 and CD30. Which of the following is true about this entity?

Select an answer:

A. Background is rich in cytotoxic T cells

B. Background lacks small B cells

C. Neoplastic cells are OCT2 positive

D. Neoplastic cells are PAX5 negative

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19 May 2020: Biweekly Image Quiz #31

Author: Lisa Rooper, M.D.

A 30 year old man presented with a destructive sinonasal tumor. Biopsy findings are shown in the photomicrograph below. What molecular alteration is thought to be the driver of this tumor?

Select an answer:

A. Mutations in IDH2

B. EWSR1 translocations

C. NUT1 translocations

D. Inactivation of SMARCB1

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