18 October 2022: Image Quiz #93

Authors: Rebecca Yoda, M.D.P.J. Cimino, M.D., Ph.D.

This IDH mutant astrocytoma is from a 40 year old woman. There is no microvascular proliferation or necrosis identified. According to the 5th edition of the WHO classification of CNS tumors (2021), a CNS WHO grade 4 should be applied if which of the following genetic alterations is present?

Select an answer:

 A. ATRX loss

B. CDKN2A homozygous deletion

C. Chromosome 1p / 19q codeletion

D. EGFR amplification

E. TERT promoter mutation

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