This is our first essay discussing malignancies and their precursor lesions based on our new Cancer Precursor Project. We have compiled a spreadsheet of all distinct human cancers (~1,230) and their identifiable precursors (~180). Please email proposed updates to Nat@PathologyOutlines.com.
Our goal is to identify precursor lesions for all malignancies to better understand and treat cancer and reduce its 600,000 annual U.S. deaths. Studying known precursors and their patterns of molecular expression may suggest molecular patterns for tumors with unknown precursors (Pernick 2018).
This essay discusses data compiled by our project on neuroendocrine tumors and summarizes current knowledge about 2 precursor lesions, one in the stomach (enterochromaffin-like cell hyperplasia) and one in the lung (diffuse idiopathic pulmonary neuroendocrine hyperplasia).
Read the full essay at pathologyoutlines.com/dw/Cancerprecursorproject-Neuroendocrinetumors.pdf.
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