18 October 2022: Image Quiz #93

Authors: Rebecca Yoda, M.D., P.J. Cimino, M.D., Ph.D.

This IDH mutant astrocytoma is from a 40 year old woman. There is no microvascular proliferation or necrosis identified. According to the 5th edition of the WHO classification of CNS tumors (2021), a CNS WHO grade 4 should be applied if which of the following genetic alterations is present?

Select an answer:

 A. ATRX loss

B. CDKN2A homozygous deletion

C. Chromosome 1p / 19q codeletion

D. EGFR amplification

E. TERT promoter mutation

See the answer

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4 October 2022: Image Quiz #92

Authors: Laura Warmke, M.D., Jeanne Meis, M.D.

Which of the following special stains is most helpful in diagnosing alveolar soft part sarcoma (ASPS)?

Select an answer:

A. Colloidal iron

B. GMS

C. PAS with diastase

D. PAS without diastase

E. Warthin-Starry

See the answer

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20 September 2022: Image Quiz #91

Author: Abberly Lott Limbach, M.D.

A 45 year old patient presents with a painless 0.5 cm white nodule on the left lateral tongue. A biopsy is performed and a representative image from the histology is shown below. What is the diagnosis?

Select an answer:

A. Fordyce granule

B. Lymphoepithelial cyst

C. Lymphoid aggregate

D. Mucocele

E. Sialolith

See the answer

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6 September 2022: Image Quiz #90

Authors: Absia Jabbar, M.D., Sonali Lanjewar, M.D., M.B.B.S., Raavi Gupta, M.D.

Exaggerated placental site (shown in the image below) is characterized by which of the following features?

Select an answer:

A. Absence of villi

B. Presence of necrosis and mitoses

C. Proliferation of chorionic type intermediate trophoblasts with invasion of myometrium

D. Proliferation of implantation type intermediate trophoblasts with invasion of myometrium

See the answer

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23 August 2022: Image Quiz #89

Authors: Ruhani Sardana, M.B.B.S., Anil Parwani, M.D., Ph.D., M.B.A.

Which technique is shown in the image below?

Select an answer:

A. Electron microscopy

B. Enzyme linked immunosorbent assay

C. Fluorescent in situ hybridization

D. Immunofluorescence

See the answer

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9 August 2022: Image Quiz #88

Authors: Zena Jameel, M.D., Marilin Rosa, M.D.

Which of the following is a relevant feature of invasive papillary carcinoma of the breast?

Select an answer:

A. Commonly encountered breast tumor

B. Graded according to nuclear size

C. May mimic metastases from other organs

D. Myoepithelial cells at the periphery

E. Positive for Napsin A and PAX8

See the answer

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26 July 2022: Image Quiz #87

Authors: Christopher Dall, M.D., Debra L. Zynger, M.D.

Teratoma with somatic type malignancy most commonly contains which histologic type?

Select an answer:

A. Adenocarcinoma

B. Primitive neuroectodermal tumor

C. Rhabdomyosarcoma

D. Sarcoma, not otherwise specified

E. Squamous cell carcinoma

See the answer

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12 July 2022: Image Quiz #86

Authors: Simona De Michele, M.D., Helen E. Remotti, M.D.

When evaluating the pulmonary neoplasm shown in the image, which immunohistochemical stain is more specific than CDX2 for ruling in a colorectal metastasis?

Select an answer:

A. CK7

B. CK20

C. Napsin A

D. SATB2

E. TTF1

See the answer

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28 June 2022: Image Quiz #85

Authors: Jutta Huvila, M.D., Ph.D., C. Blake Gilks, M.D.

Which of the following is true about benign Brenner tumors of the ovary?

Select an answer:

A. Composed of both epithelium and fibromatous stroma

B. Papillary architecture

C. Typically > 10 cm

D. Usually present with abdominal pain

See the answer

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14 June 2022: Image Quiz #84

Authors: Ameya Patil, M.D., M.S., Lizhi Zhang, M.D.

Which cell type (marked by an arrow) is considered abnormal if present in the left side of the colon?

Select an answer:

A. Enteroendocrine cells

B. Epithelial cells

C. Goblet cells

D. Paneth cells

See the answer

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