Authors: Juwairiya Arshi, M.B.B.S., Aaron R. Huber, D.O.
Which histological feature is most common in celiac disease?
Select an answer:
A. Crypt hyperplasia
B. Granulomas
C. Intraepithelial lymphocytosis
D. Mucosal eosinophilia
E. Villous atrophy
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Here is a selection of new images from our free, online textbook:
Diffuse marrow involvement by medium to large sized cells with prominent nucleoli (200x, H&E).
Contributed by Richard K. Wood, M.D. and Dietrich Werner, M.D.
Well circumscribed, firm, yellow-tan mass.
Contributed by Victoria Collins, M.D. and Tamara Kalir, M.D., Ph.D.
Here, the central zone cells are hyperplastic. Despite the cribriform structure, the bland nuclei rule out intraepithelial neoplasia or cribriform cancer. Also note the surrounding dense stroma of the central zone.
Contributed by Kenneth A. Iczkowski, M.D.
Michaelis-Gutmann bodies highlighted by arrows.
Contributed by Theodorus van der Kwast, M.D., Ph.D.
Small intestinal GIST with skeinoid fibers.
Contributed by Shefali Chopra, M.D.
Here is a selection of new images from our free, online textbook:
Classic low power cauliflower-like configuration with smooth borders.
Contributed by Nelli S. Lakis M.D., M.Sc.
Sheets of undifferentiated malignant epithelial cells with vesicular nuclear chromatin and prominent nucleoli.
Contributed by Bin Xu, M.D., Ph.D. and Abeer Salama, M.D.
Intraplacental choriocarcinoma showing atypical syncytiotrophoblast, cytotrophoblast and intermediate trophoblast adjacent to uninvolved chorionic villi (H&E, 200x).
Contributed by Tatyana Zinger, D.O.
Polypoid lesion predominantly lined by gastric foveolar epithelium and small intestinal epithelium on the left side.
Contributed by Khalid Amin, M.D.
HNF1A mutated hepatocellular adenoma: low power view showing well defined border between the lesion (right) and background liver (left).
Contributed by Monica Abdelmalak, M.D.
Here is a selection of new images from our free, online textbook:
Hyperkeratosis, papillomatosis, hypergranulosis, koilocytosis and inward bending of rete ridges at borders of lesion. Dermal papillae show dilated capillaries.
Contributed by Heba Ahmed Abdelkader, M.D.
Scanning magnification shows the dilated lymphatics in the submucosa of the small intestine (H&E, 2x).
Contributed by Haider A. Mejbel, M.D.
High power view of PGA showing small tubular glands with low cuboidal epithelium and bland nuclei.
Contributed by Supriya Srivastava M.D., Ph.D.
Nodular thyroid.
Contributed by Andrey Bychkov, M.D., Ph.D.
Anastomosing thin trabeculae of mildly atypical epithelioid and spindled cells within fibrous stroma.
Contributed by Borislav A. Alexiev, M.D.
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Here is a selection of new images from our free, online textbook:
Invasive adenocarcinoma, pattern B (H&E stain). Early destructive invasion, in an otherwise well differentiated (pattern A) neoplasm is seen as small irregular glands with prominent inflammation and stromal desmoplasia.
Contributed by Carlos Parra-Herran, M.D.
Score 3+, HER2 IHC: the tumor cells of this colorectal adenocarcinoma show strong circumferential membrane staining (200x).
Contributed by Roula Katerji, M.D. and Aaron R. Huber, D.O.
Infantile fibrosarcoma spectrum of tumors – neonate at birth with a lower thigh mass harboring a TPM3-NTRK1 fusion: panTRK antibody with cytoplasmic expression (400x).
Contributed by Jessica L. Davis, M.D.
Hepatectomy for hepatocellular carcinoma demonstrating large cytoplasmic hyaline eosinophilic inclusions and trabecular architecture (400x).
Contributed by Irene Y. Chen, M.D.
Diagnostic low magnification frozen section image showing complex glandular architecture and desmoplastic stromal reaction (H&E, 40x).
Contributed by Krutika S. Patel, M.B.B.S., M.D. and Annika L. Windon, M.D.
For desktop / tablet, you can either use the Google search bar in the upper right corner or visit PathologyOutlines.com and then scroll down to where the 60 chapters are listed, as demonstrated below.
For mobile, visit PathologyOutlines.com, click on “Chapters by Subspecialty” (as demonstrated below) and then click on the subspecialty, chapter and topic.
For any device you can use your favorite browser and type in PathologyOutlines.com in addition to the search term.
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